DegronMD

Uniprot ID: Q5JVX7

Source protein: Uncharacterized protein C1orf141

Source gene: C1orf141

Class: DEG_APCC_KENBOX_2

Location: 150:154

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9861

ASA_SCORE: 104.16

COIL: 0.6844

CONS_SCORE: 0.719

DSS_SCORE: 0.5033

HELIX: 0.2316

FCONS_SCORE: 1.3828

RIG_SCORE: 0.7733

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S162R	TCGA-17-Z043	LUAD	TCGA	IKENK	DEG_APCC_KENBOX_2	0.1111
p.R157S	TCGA-55-7994	LUAD	TCGA	IKENK	DEG_APCC_KENBOX_2	0.25
p.R157S	DO45311	LUAD	ICGC	IKENK	DEG_APCC_KENBOX_2	0.25
p.D147N	TCGA-A5-A0G2	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	0.25
p.D147N	TCGA-AZ-4315	COAD	TCGA	IKENK	DEG_APCC_KENBOX_2	0.25
p.D147N	TCGA-CA-6718	COAD	TCGA	IKENK	DEG_APCC_KENBOX_2	0.25
p.D147N	TCGA-FW-A3R5	SKCM	TCGA	IKENK	DEG_APCC_KENBOX_2	0.25
p.D147N	DO7801	COAD	ICGC	IKENK	DEG_APCC_KENBOX_2	0.25
p.D147N	DO8842	COAD	ICGC	IKENK	DEG_APCC_KENBOX_2	0.25
p.D147N	DO37406	SKCM	ICGC	IKENK	DEG_APCC_KENBOX_2	0.25
p.D147N	DO41235	UCEC	ICGC	IKENK	DEG_APCC_KENBOX_2	0.25
p.S155L	TCGA-AA-A010	COAD	TCGA	IKENK	DEG_APCC_KENBOX_2	0.3056
p.S155L	TCGA-AN-A046	BRCA	TCGA	IKENK	DEG_APCC_KENBOX_2	0.3056
p.S155L	DO1285	BRCA	ICGC	IKENK	DEG_APCC_KENBOX_2	0.3056
p.R157I	TCGA-AJ-A5DW	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	0.25
p.R157I	DO50075	UCEC	ICGC	IKENK	DEG_APCC_KENBOX_2	0.25
p.S142Y	TCGA-CA-6717	COAD	TCGA	IKENK	DEG_APCC_KENBOX_2	0.1111
p.S142Y	DO8264	COAD	ICGC	IKENK	DEG_APCC_KENBOX_2	0.1111
p.S142Y	DO50329	ESAD	ICGC	IKENK	DEG_APCC_KENBOX_2	0.1111
p.P143S	TCGA-ER-A42L	SKCM	TCGA	IKENK	DEG_APCC_KENBOX_2	0.1389
p.P143S	DO223910	SKCM	ICGC	IKENK	DEG_APCC_KENBOX_2	0.1389
p.K154T	DO1118	BRCA	ICGC	IKENK	DEG_APCC_KENBOX_2	0.6195
p.S142F	DO229050	LICA	ICGC	IKENK	DEG_APCC_KENBOX_2	0.1111
p.S142F	DO50970	LICA	ICGC	IKENK	DEG_APCC_KENBOX_2	0.1111
p.N146S	DO48709	LIRI	ICGC	IKENK	DEG_APCC_KENBOX_2	0.2222
p.Q144R	DO52365	LUSC	ICGC	IKENK	DEG_APCC_KENBOX_2	0.1667
p.M145R	SIDM01179	Other Sarcomas	GDSC	IKENK	DEG_APCC_KENBOX_2	0.1944
p.M145R	SIDM00485	Oral Cavity Carcinoma	GDSC	IKENK	DEG_APCC_KENBOX_2	0.1944
p.M145R	SIDM00975	Melanoma	GDSC	IKENK	DEG_APCC_KENBOX_2	0.1944
p.S150L	SIDM01126	Small Cell Lung Carcinoma	GDSC	IKENK	DEG_APCC_KENBOX_2	0.7667
p.L160P	SIDM00856	Other Solid Cancers	GDSC	IKENK	DEG_APCC_KENBOX_2	0.1667
p.K154N	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	IKENK	DEG_APCC_KENBOX_2	0.5806
p.K154N	ACH-000434	Lung Cancer	CCLE	IKENK	DEG_APCC_KENBOX_2	0.5806
p.N146K	ACH-000608	Ovarian Cancer	CCLE	IKENK	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60476	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB	DEG_APCC_KENBOX_2	150:154	IKENK	APC,CDC20,FZR1	0.9671	More...
Q6IQ19	Centriole, cilia and spindle-associated protein	DEG_APCC_KENBOX_2	177:181	IKENK	APC,CDC20,FZR1	0.5499	More...
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_APCC_KENBOX_2	150:154	IKENK	APC,CDC20,FZR1	0.9324	More...
Q5RHP9	Glutamate-rich protein 3	DEG_APCC_KENBOX_2	445:449	IKENK	APC,CDC20,FZR1	0.8691	More...
Q5JVX7	Uncharacterized protein C1orf141	DEG_APCC_KENBOX_2	150:154	IKENK	APC,CDC20,FZR1	0.9861	More...
Q5TEZ5	Uncharacterized protein C6orf163	DEG_APCC_KENBOX_2	321:325	IKENK	APC,CDC20,FZR1	0.8269	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IKENK

Degron related mutations and impact score

Drug responses associated with C1orf141 mutations

All proteins holding degron of IKENK