DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
C6orf163
UniProt ID:
Q5TEZ5
Entrez ID:
206412
Protein name:
Uncharacterized protein C6orf163
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
C6orf163
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.L319I
TCGA-EO-A3AY
UCEC
TCGA
IKENK
DEG_APCC_KENBOX_2
321:325
Mutation rewiring degron network
0.2778
p.L319I
DO43202
UCEC
ICGC
IKENK
DEG_APCC_KENBOX_2
321:325
Mutation rewiring degron network
0.2778
p.V320L
SIDM00640
Mesothelioma
GDSC
IKENK
DEG_APCC_KENBOX_2
321:325
Mutation rewiring degron network
0.3056
p.V320L
ACH-000335
Lung Cancer
CCLE
IKENK
DEG_APCC_KENBOX_2
321:325
Mutation rewiring degron network
0.3056
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for C6orf163 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc