DegronMD - Q5JVX7(C1orf141)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V129A	TCGA-02-2483	GBM	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.6936
p.V129A	DO12352	GBM	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.6936
p.S162R	TCGA-17-Z043	LUAD	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1111
p.R157S	TCGA-55-7994	LUAD	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.25
p.R157S	DO45311	LUAD	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.25
p.R136T	TCGA-78-7146	LUAD	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1667
p.R136T	DO23717	LUAD	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1667
p.D147N	TCGA-A5-A0G2	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.25
p.D147N	TCGA-AZ-4315	COAD	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.25
p.D147N	TCGA-CA-6718	COAD	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.25
p.D147N	TCGA-FW-A3R5	SKCM	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.25
p.D147N	DO7801	COAD	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.25
p.D147N	DO8842	COAD	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.25
p.D147N	DO37406	SKCM	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.25
p.D147N	DO41235	UCEC	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.25
p.S155L	TCGA-AA-A010	COAD	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.3056
p.S155L	TCGA-AN-A046	BRCA	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.3056
p.S155L	DO1285	BRCA	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.3056
p.N137D	TCGA-AJ-A3EL	UCEC	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1389
p.N137D	DO41542	UCEC	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1389
p.R157I	TCGA-AJ-A5DW	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.25
p.R157I	DO50075	UCEC	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.25
p.R136K	TCGA-AP-A056	UCEC	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1667
p.R136K	DO43971	UCEC	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1667
p.R136I	TCGA-AP-A1DV	UCEC	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1667
p.R136I	TCGA-EO-A3B0	UCEC	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1667
p.R136I	DO219773	UCEC	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1667
p.R136I	DO43186	UCEC	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1667
p.G130D	TCGA-AX-A05Z	UCEC	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.6087
p.G130D	DO40884	UCEC	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.6087
p.L131F	TCGA-BR-8361	STAD	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.3056
p.L131F	DO48032	STAD	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.3056
p.S142Y	TCGA-CA-6717	COAD	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1111
p.S142Y	DO8264	COAD	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1111
p.S142Y	DO50329	ESAD	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1111
p.S128F	TCGA-EE-A20F	SKCM	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.6871
p.S128F	TCGA-EY-A1GI	UCEC	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.6871
p.S128F	DO37961	SKCM	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.6871
p.S128F	DO41211	UCEC	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.6871
p.P143S	TCGA-ER-A42L	SKCM	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1389
p.P143S	DO223910	SKCM	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1389
p.E119K	TCGA-FR-A726	SKCM	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.25
p.E119K	DO48665	SKCM	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.25
p.S114L	TCGA-XF-A8HG	BLCA	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1111
p.S114L	DO49802	BLCA	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1111
p.E133G	DO224667	BRCA	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.25
p.E133G	DO1103	BRCA	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.25
p.K154T	DO1118	BRCA	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation altering degron motif	0.6195
p.T115K	DO229018	LICA	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1389
p.S142F	DO229050	LICA	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1111
p.S142F	DO50970	LICA	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1111
p.N146S	DO48709	LIRI	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.2222
p.Q144R	DO52365	LUSC	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1667
p.K138E	DO231179	LUSC	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation substituting flanking lysine	0.2222
p.M145R	SIDM01179	Other Sarcomas	GDSC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1944
p.M145R	SIDM00485	Oral Cavity Carcinoma	GDSC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1944
p.M145R	SIDM00975	Melanoma	GDSC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1944
p.S150L	SIDM01126	Small Cell Lung Carcinoma	GDSC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation altering degron motif	0.7667
p.A116V	SIDM00193	Colorectal Carcinoma	GDSC	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1667
p.R128I	SIDM00193	Colorectal Carcinoma	GDSC	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.8102
p.L160P	SIDM00856	Other Solid Cancers	GDSC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1667
p.K154N	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation altering degron motif	0.5806
p.K154N	ACH-000434	Lung Cancer	CCLE	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation altering degron motif	0.5806
p.R123T	SIDM00094	Kidney Carcinoma	GDSC	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.7876
p.R123T	ACH-002199	Kidney Cancer	CCLE	PRKPLDSVG	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.7876
p.N146K	ACH-000608	Ovarian Cancer	CCLE	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C1orf141

UniProt ID: Q5JVX7

Entrez ID: 400757

Protein name: Uncharacterized protein C1orf141

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C1orf141 in