DegronMD

Uniprot ID: Q5JVX7

Source protein: Uncharacterized protein C1orf141

Source gene: C1orf141

Class: DEG_APCC_DBOX_1

Location: 122:130

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8411

ASA_SCORE: 84.4556

COIL: 0.8066

CONS_SCORE: 0.5082

DSS_SCORE: 0.6034

HELIX: 0.0902

FCONS_SCORE: 0.9917

RIG_SCORE: 0.6891

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V129A	TCGA-02-2483	GBM	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	0.6936
p.V129A	DO12352	GBM	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	0.6936
p.R136T	TCGA-78-7146	LUAD	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	0.1667
p.R136T	DO23717	LUAD	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	0.1667
p.N137D	TCGA-AJ-A3EL	UCEC	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	0.1389
p.N137D	DO41542	UCEC	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	0.1389
p.R136K	TCGA-AP-A056	UCEC	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	0.1667
p.R136K	DO43971	UCEC	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	0.1667
p.R136I	TCGA-AP-A1DV	UCEC	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	0.1667
p.R136I	TCGA-EO-A3B0	UCEC	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	0.1667
p.R136I	DO219773	UCEC	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	0.1667
p.R136I	DO43186	UCEC	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	0.1667
p.G130D	TCGA-AX-A05Z	UCEC	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	0.6087
p.G130D	DO40884	UCEC	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	0.6087
p.L131F	TCGA-BR-8361	STAD	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	0.3056
p.L131F	DO48032	STAD	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	0.3056
p.S128F	TCGA-EE-A20F	SKCM	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	0.6871
p.S128F	TCGA-EY-A1GI	UCEC	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	0.6871
p.S128F	DO37961	SKCM	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	0.6871
p.S128F	DO41211	UCEC	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	0.6871
p.E119K	TCGA-FR-A726	SKCM	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	0.25
p.E119K	DO48665	SKCM	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	0.25
p.S114L	TCGA-XF-A8HG	BLCA	TCGA	PRKPLDSVG	DEG_APCC_DBOX_1	0.1111
p.S114L	DO49802	BLCA	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	0.1111
p.E133G	DO224667	BRCA	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	0.25
p.E133G	DO1103	BRCA	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	0.25
p.T115K	DO229018	LICA	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	0.1389
p.K138E	DO231179	LUSC	ICGC	PRKPLDSVG	DEG_APCC_DBOX_1	0.2222
p.A116V	SIDM00193	Colorectal Carcinoma	GDSC	PRKPLDSVG	DEG_APCC_DBOX_1	0.1667
p.R128I	SIDM00193	Colorectal Carcinoma	GDSC	PRKPLDSVG	DEG_APCC_DBOX_1	0.8102
p.R123T	SIDM00094	Kidney Carcinoma	GDSC	PRKPLDSVG	DEG_APCC_DBOX_1	0.7876
p.R123T	ACH-002199	Kidney Cancer	CCLE	PRKPLDSVG	DEG_APCC_DBOX_1	0.7876

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRKPLDSVG

Degron related mutations and impact score

Drug responses associated with C1orf141 mutations

All proteins holding degron of PRKPLDSVG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JVX7	Uncharacterized protein C1orf141	DEG_APCC_DBOX_1	122:130	PRKPLDSVG	APC,CDC20,FZR1	0.8411	More...