DegronMD - Q6IQ19(CCSAP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I177R	TCGA-AP-A1DV	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	177:181	Mutation altering degron motif	0.6991
p.P183L	TCGA-DF-A2KU	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	177:181	Mutation rewiring degron network	0.2778
p.R172I	TCGA-EO-A22R	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	177:181	Mutation rewiring degron network	0.1944
p.R172I	DO42713	UCEC	ICGC	IKENK	DEG_APCC_KENBOX_2	177:181	Mutation rewiring degron network	0.1944
p.S174L	TCGA-GF-A6C9	SKCM	TCGA	IKENK	DEG_APCC_KENBOX_2	177:181	Mutation rewiring degron network	0.25
p.S174L	DO51254	SKCM	ICGC	IKENK	DEG_APCC_KENBOX_2	177:181	Mutation rewiring degron network	0.25
p.H182N	SIDM00301	Pancreatic Carcinoma	GDSC	IKENK	DEG_APCC_KENBOX_2	177:181	Mutation rewiring degron network	0.3056
p.H182N	ACH-000265	Pancreatic Cancer	CCLE	IKENK	DEG_APCC_KENBOX_2	177:181	Mutation rewiring degron network	0.3056
p.H182N	KP-4	pancreas	COSMIC	IKENK	DEG_APCC_KENBOX_2	177:181	Mutation rewiring degron network	0.3056
p.F184L	SIDM01451	Pancreatic Carcinoma	GDSC	IKENK	DEG_APCC_KENBOX_2	177:181	Mutation rewiring degron network	0.25
p.F184L	ACH-000933	Pancreatic Cancer	CCLE	IKENK	DEG_APCC_KENBOX_2	177:181	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons