DegronMD - Q86TM6(SYVN1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A547V	TCGA-B5-A3FC	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1667
p.A547V	DO41871	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1667
p.M578I	TCGA-L5-A4OE	ESCA	TCGA	PTPGAS	DEG_SCF_FBW7_1	567:572	Mutation rewiring degron network	0.1667
p.S561R	TCGA-OR-A5LC	ACC	TCGA	PTPGAS	DEG_SCF_FBW7_1	567:572	Mutation rewiring degron network	0.1667
p.S561R	TCGA-OR-A5LC	ACC	TCGA	AASST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2222
p.S561R	DO229027	LICA	ICGC	PTPGAS	DEG_SCF_FBW7_1	567:572	Mutation rewiring degron network	0.1667
p.S561R	DO229027	LICA	ICGC	AASST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2222
p.R607C	TCGA-PG-A5BC	UCEC	TCGA	RRRRLQKLE	DEG_APCC_DBOX_1	604:612	Mutation altering degron motif	0.719
p.R607C	DO48171	UCEC	ICGC	RRRRLQKLE	DEG_APCC_DBOX_1	604:612	Mutation altering degron motif	0.719
p.S415T	TCGA-UY-A78K	BLCA	TCGA	PPSTS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.1944
p.S415T	DO219031	BLCA	ICGC	PPSTS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.1944
p.P417R	TCGA-VQ-AA6D	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.1389
p.P417R	DO222392	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.1389
p.A403S	DO48987	CESC	ICGC	PPSTS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.25
p.L607P	DO233732	GACA	ICGC	RRRRLQKLE	DEG_APCC_DBOX_1	604:612	Mutation altering degron motif	0.7582
p.P567R	DO233876	GACA	ICGC	PTPGAS	DEG_SCF_FBW7_1	567:572	Mutation altering degron motif	0.7512
p.R606S	DO229019	LICA	ICGC	RRRRLQKLE	DEG_APCC_DBOX_1	604:612	Mutation altering degron motif	0.6316
p.R605G	DO23496	LINC	ICGC	RRRRLQKLE	DEG_APCC_DBOX_1	604:612	Mutation altering degron motif	0.7568
p.R605G	DO45053	LINC	ICGC	RRRRLQKLE	DEG_APCC_DBOX_1	604:612	Mutation altering degron motif	0.7568
p.L611M	DO23330	LINC	ICGC	RRRRLQKLE	DEG_APCC_DBOX_1	604:612	Mutation altering degron motif	0.5999
p.S555Y	DO27889	ORCA	ICGC	AASST	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.712
p.S418I	DO232445	PBCA	ICGC	PPSTS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.1111
p.S399I	DO229240	THCA	ICGC	PPSTS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.1389
p.R606H	SIDM01943	Colorectal Carcinoma	GDSC	RRRRLQKLE	DEG_APCC_DBOX_1	604:612	Mutation altering degron motif	0.7133
p.P398A	SIDM01058	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPSTS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.1111
p.P398A	ACH-000073	Lymphoma	CCLE	PPSTS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.1111
p.P398A	GRANTA-519	haematopoietic and lymphoid tissue	COSMIC	PPSTS	DEG_SPOP_SBC_1	406:410	Mutation rewiring degron network	0.1111
p.P614H	SIDM00120	Prostate Carcinoma	GDSC	RRRRLQKLE	DEG_APCC_DBOX_1	604:612	Mutation rewiring degron network	0.2778
p.P614H	ACH-000979	Prostate Cancer	CCLE	RRRRLQKLE	DEG_APCC_DBOX_1	604:612	Mutation rewiring degron network	0.2778
p.P614H	DU-145	prostate	COSMIC	RRRRLQKLE	DEG_APCC_DBOX_1	604:612	Mutation rewiring degron network	0.2778
p.L611P	SIDM00487	Colorectal Carcinoma	GDSC	RRRRLQKLE	DEG_APCC_DBOX_1	604:612	Mutation altering degron motif	0.7582
p.L611P	ACH-000963	Colon/Colorectal Cancer	CCLE	RRRRLQKLE	DEG_APCC_DBOX_1	604:612	Mutation altering degron motif	0.7582
p.L611P	CCK-81	large intestine	COSMIC	RRRRLQKLE	DEG_APCC_DBOX_1	604:612	Mutation altering degron motif	0.7582
p.A616T	SIDM00954	Breast Carcinoma	GDSC	RRRRLQKLE	DEG_APCC_DBOX_1	604:612	Mutation rewiring degron network	0.2222
p.A616T	COLO-824	breast	COSMIC	RRRRLQKLE	DEG_APCC_DBOX_1	604:612	Mutation rewiring degron network	0.2222
p.P562H	DU-145	prostate	COSMIC	PTPGAS	DEG_SCF_FBW7_1	567:572	Mutation blocking phosphorylation signal	0.6389
p.P562H	DU-145	prostate	COSMIC	AASST	DEG_SPOP_SBC_1	553:557	Mutation blocking phosphorylation signal	0.6389
p.V550A	PCI-38	upper aerodigestive tract	COSMIC	AASST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.25
p.L559P	CCK-81	large intestine	COSMIC	PTPGAS	DEG_SCF_FBW7_1	567:572	Mutation rewiring degron network	0.1111
p.L559P	CCK-81	large intestine	COSMIC	AASST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778
p.A564T	COLO-824	breast	COSMIC	PTPGAS	DEG_SCF_FBW7_1	567:572	Mutation rewiring degron network	0.25
p.A564T	COLO-824	breast	COSMIC	AASST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1389
p.L610P	CCK-81	large intestine	COSMIC	RRRRLQKLE	DEG_APCC_DBOX_1	604:612	Mutation altering degron motif	0.7582
p.P613H	DU-145	prostate	COSMIC	RRRRLQKLE	DEG_APCC_DBOX_1	604:612	Mutation blocking phosphorylation signal	0.75
p.A615T	COLO-824	breast	COSMIC	RRRRLQKLE	DEG_APCC_DBOX_1	604:612	Mutation rewiring degron network	0.25
p.G410S	647-V	urinary tract	COSMIC	PPSTS	DEG_SPOP_SBC_1	406:410	Mutation altering degron motif	0.6993
p.V551A	PCI-38	upper aerodigestive tract	COSMIC	AASST	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778

Kaplan plot for SYVN1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYVN1

UniProt ID: Q86TM6

Entrez ID: 84447

Protein name: E3 ubiquitin-protein ligase synoviolin (EC 2.3.2.27) (RING-type E3 ubiquitin transferase synoviolin) (Synovial apoptosis inhibitor 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SYVN1 in