DegronMD

Uniprot ID: Q86TM6

Source protein: E3 ubiquitin-protein ligase synoviolin

Source gene: SYVN1

Class: DEG_SPOP_SBC_1

Location: 553:557

E3 ligase: SPOP

DEGRON score: 0.9772

ASA_SCORE: 89.14

COIL: 0.9306

CONS_SCORE: 0.2145

DSS_SCORE: 0.5944

HELIX: 0.0532

FCONS_SCORE: 0.9421

RIG_SCORE: 0.6465

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S555Y	DO27889	ORCA	ICGC	AASST	DEG_SPOP_SBC_1	0.712
p.P562H	DU-145	prostate	COSMIC	AASST	DEG_SPOP_SBC_1	0.6389
p.L559P	CCK-81	large_intestine	COSMIC	AASST	DEG_SPOP_SBC_1	0.2778
p.V551A	PCI-38	upper_aerodigestive_tract	COSMIC	AASST	DEG_SPOP_SBC_1	0.2778
p.V550A	PCI-38	upper_aerodigestive_tract	COSMIC	AASST	DEG_SPOP_SBC_1	0.25
p.S561R	TCGA-OR-A5LC	ACC	TCGA	AASST	DEG_SPOP_SBC_1	0.2222
p.S561R	DO229027	LICA	ICGC	AASST	DEG_SPOP_SBC_1	0.2222
p.A547V	TCGA-B5-A3FC	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	0.1667
p.A547V	DO41871	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	0.1667
p.A564T	COLO-824	breast	COSMIC	AASST	DEG_SPOP_SBC_1	0.1389

Showing 1 to 10 of 10 entries

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Drug responses associated with SYVN1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of AASST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2G4	Ankyrin repeat domain-containing protein 6	DEG_SPOP_SBC_1	637:641	AASST	SPOP	0.7804	More...
Q96P47	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	320:324	AASST	SPOP	0.9988	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	11:15	AASST	SPOP	0.92	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	525:529	AASST	SPOP	0.9018	More...
Q00587	Cdc42 effector protein 1	DEG_SPOP_SBC_1	277:281	AASST	SPOP	0.9931	More...
Q9HAF1	Chromatin modification-related protein MEAF6	DEG_SPOP_SBC_1	155:159	AASST	SPOP	0.6503	More...
Q9BTC0	Death-inducer obliterator 1	DEG_SPOP_SBC_1	1299:1303	AASST	SPOP	0.9885	More...
Q9NP87	DNA-directed DNA/RNA polymerase mu	DEG_SPOP_SBC_1	17:21	AASST	SPOP	0.983	More...
Q86TM6	E3 ubiquitin-protein ligase synoviolin	DEG_SPOP_SBC_1	553:557	AASST	SPOP	0.9772	More...
P15976	Erythroid transcription factor	DEG_SPOP_SBC_1	44:48	AASST	SPOP	0.6198	More...
Q96KP1	Exocyst complex component 2	DEG_SPOP_SBC_1	916:920	AASST	SPOP	0.9073	More...
Q07687	Homeobox protein DLX-2	DEG_SPOP_SBC_1	18:22	AASST	SPOP	0.9974	More...
Q9BYI3	Hyccin	DEG_SPOP_SBC_1	355:359	AASST	SPOP	0.9992	More...
Q8IU81	Interferon regulatory factor 2-binding protein 1	DEG_SPOP_SBC_1	455:459	AASST	SPOP	0.8522	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	1509:1513	AASST	SPOP	0.6304	More...
Q02078	Myocyte-specific enhancer factor 2A	DEG_SPOP_SBC_1	169:173	AASST	SPOP	0.6185	More...
P29966	Myristoylated alanine-rich C-kinase substrate	DEG_SPOP_SBC_1	129:133	AASST	SPOP	0.9228	More...
P12036	Neurofilament heavy polypeptide	DEG_SPOP_SBC_1	70:74	AASST	SPOP	0.9827	More...
Q9Y4A8	Nuclear factor erythroid 2-related factor 3	DEG_SPOP_SBC_1	132:136	AASST	SPOP	0.7076	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1554:1558	AASST	SPOP	0.9763	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1774:1778	AASST	SPOP	0.9839	More...
Q13516	Oligodendrocyte transcription factor 2	DEG_SPOP_SBC_1	90:94	AASST	SPOP	0.9738	More...
Q9Y2W3	Proton-associated sugar transporter A	DEG_SPOP_SBC_1	38:42	AASST	SPOP	0.9955	More...
Q9BZZ2	Sialoadhesin	DEG_SPOP_SBC_1	564:568	AASST	SPOP	0.8123	More...
Q15554	Telomeric repeat-binding factor 2	DEG_SPOP_SBC_1	291:295	AASST	SPOP	0.9947	More...

Showing 1 to 25 of 33 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AASST

Degron related mutations and impact score

Drug responses associated with SYVN1 mutations

All proteins holding degron of AASST