DegronMD - Q02078(MEF2A)

FUNCTION: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle dev... View more >>

GO - Biological processes (BP): apoptotic process [GO:0006915]; cardiac conduction [GO:0061337]; cell differentiation [GO:0030154]; cellular response to calcium ion [GO:0071277]; dendrite morphogenesis [GO:0048813]; ERK5 cascade [GO:0070375]; heart development [GO:0007507]; MAPK cascade [GO:0000165]; mitochondrial genome maintenan... View more >>

GO - Molecular function (MF): chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription factor binding ... View more >>

GO - Cellular component (CC): chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription regulator complex [GO:0005667]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	VHL	Myocyte-specific enhancer factor 2A	131:144	More..
PLATPVVS	DEG_SCF_FBW7_1	FBXW7	Myocyte-specific enhancer factor 2A	309:316	More..
VLTPHTE	DEG_SCF_FBW7_2	FBXW7	Myocyte-specific enhancer factor 2A	106:112	More..
AASST	DEG_SPOP_SBC_1	SPOP	Myocyte-specific enhancer factor 2A	169:173	More..
LTPHTE	LIG_APCC_ABBA_1	APC,CDC20,FZR1	Myocyte-specific enhancer factor 2A	107:112	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S111L	DO227943	BRCA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation altering degron motif	0.7667
p.S111L	DO227943	BRCA	ICGC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation altering degron motif	0.7667
p.G136C	DO229035	LICA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation altering degron motif	0.76
p.A312G	SNU-398	liver	COSMIC	PLATPVVS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.754
p.G137V	DO229045	LICA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation altering degron motif	0.7532
p.Y105C	DO222827	BTCA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation blocking phosphorylation signal	0.75
p.Y105C	DO35597	PBCA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation blocking phosphorylation signal	0.75
p.S108R	DO23280	LINC	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation altering degron motif	0.7427
p.S108R	DO23280	LINC	ICGC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation altering degron motif	0.7427
p.S313I	DO229029	LICA	ICGC	PLATPVVS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.7341
p.Y105C	DO222827	BTCA	ICGC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation blocking phosphorylation signal	0.7222
p.Y105C	DO35597	PBCA	ICGC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation blocking phosphorylation signal	0.7222
p.G173D	DO12976	GBM	ICGC	AASST	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.7198
p.T309A	ACH-002069	Bone Cancer	CCLE	PLATPVVS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.7139
p.S309T	DO29228	OV	ICGC	PLATPVVS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.7116
p.I131T	TCGA-2W-A8YY	CESC	TCGA	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation altering degron motif	0.7078
p.I131T	DO223732	CESC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation altering degron motif	0.7078
p.V311F	HCC1143	breast	COSMIC	PLATPVVS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.7068
p.P109T	SIDM00867	Glioblastoma	GDSC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation altering degron motif	0.7031
p.P109T	SIDM00867	Glioblastoma	GDSC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation altering degron motif	0.7031

Showing 1 to 20 of 99 entries

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Kaplan plot for MEF2A in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

MEF2A

UniProt ID: Q02078

Entrez ID: 4205

Protein name: Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MEF2A in