DegronMD - Q02078(MEF2A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I131T	TCGA-2W-A8YY	CESC	TCGA	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation altering degron motif	0.7078
p.I131T	DO223732	CESC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation altering degron motif	0.7078
p.D100Y	TCGA-37-4130	LUSC	TCGA	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation rewiring degron network	0.1667
p.D100Y	TCGA-37-4130	LUSC	TCGA	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.1389
p.D100Y	DO26490	LUSC	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation rewiring degron network	0.1667
p.D100Y	DO26490	LUSC	ICGC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.1389
p.V307M	TCGA-39-5035	LUSC	TCGA	PLATPVVS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.2778
p.G160W	TCGA-AX-A2HD	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.0833
p.I118N	TCGA-B5-A11E	UCEC	TCGA	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation rewiring degron network	0.1667
p.I118N	TCGA-B5-A11E	UCEC	TCGA	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.1667
p.I118N	DO41644	UCEC	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation rewiring degron network	0.1667
p.I118N	DO41644	UCEC	ICGC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.1667
p.K130T	TCGA-B5-A1MR	UCEC	TCGA	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.3056
p.K130T	DO41758	UCEC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.3056
p.M142L	TCGA-CD-A4MG	STAD	TCGA	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation altering degron motif	0.5999
p.S313G	TCGA-E9-A1N5	BRCA	TCGA	PLATPVVS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.6993
p.S313G	DO6195	BRCA	ICGC	PLATPVVS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.6993
p.P151S	TCGA-EB-A51B	SKCM	TCGA	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.1389
p.R127Q	TCGA-EO-A22R	UCEC	TCGA	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.2222
p.R127Q	DO222983	BTCA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.2222
p.R127Q	DO42713	UCEC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.2222
p.L180F	TCGA-EY-A215	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1389
p.L180F	DO42665	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1389
p.V144A	TCGA-F4-6854	COAD	TCGA	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation altering degron motif	0.5825
p.V144A	DO8071	COAD	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation altering degron motif	0.5825
p.G149A	DO219083	BLCA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.1944
p.S111L	DO227943	BRCA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation altering degron motif	0.7667
p.S111L	DO227943	BRCA	ICGC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation altering degron motif	0.7667
p.H110Y	DO222827	BTCA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation altering degron motif	0.6118
p.H110Y	DO222827	BTCA	ICGC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation altering degron motif	0.6118
p.Y105C	DO222827	BTCA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation blocking phosphorylation signal	0.75
p.Y105C	DO222827	BTCA	ICGC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation blocking phosphorylation signal	0.7222
p.Y105C	DO35597	PBCA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation blocking phosphorylation signal	0.75
p.Y105C	DO35597	PBCA	ICGC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation blocking phosphorylation signal	0.7222
p.P99S	DO222827	BTCA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation rewiring degron network	0.1389
p.P99S	DO222827	BTCA	ICGC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.1111
p.P99S	DO35597	PBCA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation rewiring degron network	0.1389
p.P99S	DO35597	PBCA	ICGC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.1111
p.F124L	DO9876	COAD	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.1389
p.G173D	DO12976	GBM	ICGC	AASST	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.7198
p.D121V	DO52054	HNSC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.0556
p.D121V	DO52054	HNSC	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation rewiring degron network	0.0833
p.D121V	DO52054	HNSC	ICGC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0833
p.M142I	DO229019	LICA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation altering degron motif	0.6507
p.S313I	DO229029	LICA	ICGC	PLATPVVS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.7341
p.D176Y	DO229034	LICA	ICGC	AASST	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.E106D	DO229035	LICA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation altering degron motif	0.6758
p.E106D	DO229037	LICA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation altering degron motif	0.6758
p.G136C	DO229035	LICA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation altering degron motif	0.76
p.V106L	DO229041	LICA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation altering degron motif	0.5654
p.E112D	DO229045	LICA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation altering degron motif	0.6758
p.E112D	DO229045	LICA	ICGC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation altering degron motif	0.5647
p.G137V	DO229045	LICA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation altering degron motif	0.7532
p.D102E	DO44883	LIHC	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation rewiring degron network	0.2222
p.D102E	DO44883	LIHC	ICGC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.1944
p.K130N	DO23220	LINC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.3056
p.K130N	DO23146	LINC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.3056
p.S108R	DO23280	LINC	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation altering degron motif	0.7427
p.S108R	DO23280	LINC	ICGC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation altering degron motif	0.7427
p.N119S	DO23308	LINC	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation rewiring degron network	0.1389
p.N119S	DO23308	LINC	ICGC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.1389
p.P126S	DO26536	LUSC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.1944
p.P126S	DO220872	MELA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.1944
p.P126S	DO37406	SKCM	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.1944
p.P126S	DO38153	SKCM	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.1944
p.D97N	DO222837	MELA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation rewiring degron network	0.0833
p.D97N	DO222837	MELA	ICGC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.S309T	DO29228	OV	ICGC	PLATPVVS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.7116
p.G129C	DO46657	PAAD	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.2778
p.S122F	DO47747	STAD	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.0833
p.S122F	DO47747	STAD	ICGC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation rewiring degron network	0.0556
p.S122F	DO47747	STAD	ICGC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.0556
p.N167K	DO42312	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.2778
p.D143N	DO41871	UCEC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation altering degron motif	0.6932
p.R127W	SIDM01293	Colorectal Carcinoma	GDSC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.2222
p.R127W	ACH-000990	Endometrial/Uterine Cancer	CCLE	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.2222
p.S98N	SIDM00523	Small Cell Lung Carcinoma	GDSC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation blocking phosphorylation signal	0.5556
p.S98N	SIDM00523	Small Cell Lung Carcinoma	GDSC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation blocking phosphorylation signal	0.5278
p.S98N	ACH-000698	Lung Cancer	CCLE	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation blocking phosphorylation signal	0.5556
p.S98N	ACH-000698	Lung Cancer	CCLE	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation blocking phosphorylation signal	0.5278
p.S98N	DMS-53	lung	COSMIC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation blocking phosphorylation signal	0.5556
p.S98N	DMS-53	lung	COSMIC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation blocking phosphorylation signal	0.5278
p.P109T	SIDM00867	Glioblastoma	GDSC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation altering degron motif	0.7031
p.P109T	SIDM00867	Glioblastoma	GDSC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation altering degron motif	0.7031
p.P109T	DBTRG-05MG	central nervous system	COSMIC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation altering degron motif	0.7031
p.P109T	DBTRG-05MG	central nervous system	COSMIC	LTPHTE	LIG_APCC_ABBA_1	107:112	Mutation altering degron motif	0.7031
p.C96Y	SIDM00171	Colorectal Carcinoma	GDSC	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation rewiring degron network	0.0556
p.C96Y	ACH-000412	Colon/Colorectal Cancer	CCLE	VLTPHTE	DEG_SCF_FBW7_2	106:112	Mutation rewiring degron network	0.0556
p.M125V	SIDM01520	Oral Cavity Carcinoma	GDSC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.1667
p.M125V	ACH-000503	Head and Neck Cancer	CCLE	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	131:144	Mutation rewiring degron network	0.1667
p.L300F	ACH-000829	Myeloma	CCLE	PLATPVVS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.0833
p.S165Y	ACH-001864	Bile Duct Cancer	CCLE	AASST	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.2222
p.S175L	ACH-001864	Bile Duct Cancer	CCLE	AASST	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.2778
p.T309A	ACH-002069	Bone Cancer	CCLE	PLATPVVS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.7139
p.V303F	HCC1143	breast	COSMIC	PLATPVVS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.1667
p.M181I	CAL-62	thyroid	COSMIC	AASST	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1111
p.A312G	SNU-398	liver	COSMIC	PLATPVVS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.754
p.A304G	SNU-398	liver	COSMIC	PLATPVVS	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.1944
p.V311F	HCC1143	breast	COSMIC	PLATPVVS	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.7068

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MEF2A

UniProt ID: Q02078

Entrez ID: 4205

Protein name: Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MEF2A in