DegronMD

Uniprot ID: Q02078

Source protein: Myocyte-specific enhancer factor 2A

Source gene: MEF2A

Class: DEG_SCF_FBW7_2

Location: 106:112

E3 ligase: FBXW7

DEGRON score: 0.9034

ASA_SCORE: 83.7

COIL: 0.7439

CONS_SCORE: 0.3221

DSS_SCORE: 0.5607

HELIX: 0.2289

FCONS_SCORE: 0.9279

RIG_SCORE: 0.7366

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S111L	DO227943	BRCA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	0.7667
p.Y105C	DO222827	BTCA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	0.75
p.Y105C	DO35597	PBCA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	0.75
p.S108R	DO23280	LINC	ICGC	VLTPHTE	DEG_SCF_FBW7_2	0.7427
p.P109T	SIDM00867	Glioblastoma	GDSC	VLTPHTE	DEG_SCF_FBW7_2	0.7031
p.P109T	DBTRG-05MG	central_nervous_system	COSMIC	VLTPHTE	DEG_SCF_FBW7_2	0.7031
p.E106D	DO229035	LICA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	0.6758
p.E106D	DO229037	LICA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	0.6758
p.E112D	DO229045	LICA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	0.6758
p.H110Y	DO222827	BTCA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	0.6118
p.V106L	DO229041	LICA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	0.5654
p.S98N	SIDM00523	Small Cell Lung Carcinoma	GDSC	VLTPHTE	DEG_SCF_FBW7_2	0.5556
p.S98N	ACH-000698	Lung Cancer	CCLE	VLTPHTE	DEG_SCF_FBW7_2	0.5556
p.S98N	DMS-53	lung	COSMIC	VLTPHTE	DEG_SCF_FBW7_2	0.5556
p.D102E	DO44883	LIHC	ICGC	VLTPHTE	DEG_SCF_FBW7_2	0.2222
p.D100Y	TCGA-37-4130	LUSC	TCGA	VLTPHTE	DEG_SCF_FBW7_2	0.1667
p.D100Y	DO26490	LUSC	ICGC	VLTPHTE	DEG_SCF_FBW7_2	0.1667
p.I118N	TCGA-B5-A11E	UCEC	TCGA	VLTPHTE	DEG_SCF_FBW7_2	0.1667
p.I118N	DO41644	UCEC	ICGC	VLTPHTE	DEG_SCF_FBW7_2	0.1667
p.P99S	DO222827	BTCA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	0.1389
p.P99S	DO35597	PBCA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	0.1389
p.N119S	DO23308	LINC	ICGC	VLTPHTE	DEG_SCF_FBW7_2	0.1389
p.D121V	DO52054	HNSC	ICGC	VLTPHTE	DEG_SCF_FBW7_2	0.0833
p.D97N	DO222837	MELA	ICGC	VLTPHTE	DEG_SCF_FBW7_2	0.0833
p.S122F	DO47747	STAD	ICGC	VLTPHTE	DEG_SCF_FBW7_2	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02078	Myocyte-specific enhancer factor 2A	DEG_SCF_FBW7_2	106:112	VLTPHTE	FBXW7	0.9034	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons