DegronMD

Uniprot ID: Q02078

Source protein: Myocyte-specific enhancer factor 2A

Source gene: MEF2A

Class: DEG_SCF_FBW7_1

Location: 309:316

E3 ligase: FBXW7

DEGRON score: 0.9953

ASA_SCORE: 83.7375

COIL: 0.9234

CONS_SCORE: 0.3492

DSS_SCORE: 0.5165

HELIX: 0.0287

FCONS_SCORE: 1.1108

RIG_SCORE: 0.7154

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V307M	TCGA-39-5035	LUSC	TCGA	PLATPVVS	DEG_SCF_FBW7_1	0.2778
p.S313G	TCGA-E9-A1N5	BRCA	TCGA	PLATPVVS	DEG_SCF_FBW7_1	0.6993
p.S313G	DO6195	BRCA	ICGC	PLATPVVS	DEG_SCF_FBW7_1	0.6993
p.S313I	DO229029	LICA	ICGC	PLATPVVS	DEG_SCF_FBW7_1	0.7341
p.S309T	DO29228	OV	ICGC	PLATPVVS	DEG_SCF_FBW7_1	0.7116
p.L300F	ACH-000829	Myeloma	CCLE	PLATPVVS	DEG_SCF_FBW7_1	0.0833
p.T309A	ACH-002069	Bone Cancer	CCLE	PLATPVVS	DEG_SCF_FBW7_1	0.7139
p.V303F	HCC1143	breast	COSMIC	PLATPVVS	DEG_SCF_FBW7_1	0.1667
p.A312G	SNU-398	liver	COSMIC	PLATPVVS	DEG_SCF_FBW7_1	0.754
p.A304G	SNU-398	liver	COSMIC	PLATPVVS	DEG_SCF_FBW7_1	0.1944
p.V311F	HCC1143	breast	COSMIC	PLATPVVS	DEG_SCF_FBW7_1	0.7068

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02078	Myocyte-specific enhancer factor 2A	DEG_SCF_FBW7_1	309:316	PLATPVVS	FBXW7	0.9953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons