DegronMD

Uniprot ID: Q02078

Source protein: Myocyte-specific enhancer factor 2A

Source gene: MEF2A

Class: LIG_APCC_ABBA_1

Location: 107:112

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9741

ASA_SCORE: 82.8

COIL: 0.7335

CONS_SCORE: 0.3306

DSS_SCORE: 0.5605

HELIX: 0.2435

FCONS_SCORE: 0.9726

RIG_SCORE: 0.7414

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D100Y	TCGA-37-4130	LUSC	TCGA	LTPHTE	LIG_APCC_ABBA_1	0.1389
p.D100Y	DO26490	LUSC	ICGC	LTPHTE	LIG_APCC_ABBA_1	0.1389
p.I118N	TCGA-B5-A11E	UCEC	TCGA	LTPHTE	LIG_APCC_ABBA_1	0.1667
p.I118N	DO41644	UCEC	ICGC	LTPHTE	LIG_APCC_ABBA_1	0.1667
p.S111L	DO227943	BRCA	ICGC	LTPHTE	LIG_APCC_ABBA_1	0.7667
p.H110Y	DO222827	BTCA	ICGC	LTPHTE	LIG_APCC_ABBA_1	0.6118
p.Y105C	DO222827	BTCA	ICGC	LTPHTE	LIG_APCC_ABBA_1	0.7222
p.Y105C	DO35597	PBCA	ICGC	LTPHTE	LIG_APCC_ABBA_1	0.7222
p.P99S	DO222827	BTCA	ICGC	LTPHTE	LIG_APCC_ABBA_1	0.1111
p.P99S	DO35597	PBCA	ICGC	LTPHTE	LIG_APCC_ABBA_1	0.1111
p.D121V	DO52054	HNSC	ICGC	LTPHTE	LIG_APCC_ABBA_1	0.0833
p.E112D	DO229045	LICA	ICGC	LTPHTE	LIG_APCC_ABBA_1	0.5647
p.D102E	DO44883	LIHC	ICGC	LTPHTE	LIG_APCC_ABBA_1	0.1944
p.S108R	DO23280	LINC	ICGC	LTPHTE	LIG_APCC_ABBA_1	0.7427
p.N119S	DO23308	LINC	ICGC	LTPHTE	LIG_APCC_ABBA_1	0.1389
p.D97N	DO222837	MELA	ICGC	LTPHTE	LIG_APCC_ABBA_1	0.0556
p.S122F	DO47747	STAD	ICGC	LTPHTE	LIG_APCC_ABBA_1	0.0556
p.S98N	SIDM00523	Small Cell Lung Carcinoma	GDSC	LTPHTE	LIG_APCC_ABBA_1	0.5278
p.S98N	ACH-000698	Lung Cancer	CCLE	LTPHTE	LIG_APCC_ABBA_1	0.5278
p.S98N	DMS-53	lung	COSMIC	LTPHTE	LIG_APCC_ABBA_1	0.5278
p.P109T	SIDM00867	Glioblastoma	GDSC	LTPHTE	LIG_APCC_ABBA_1	0.7031
p.P109T	DBTRG-05MG	central_nervous_system	COSMIC	LTPHTE	LIG_APCC_ABBA_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02078	Myocyte-specific enhancer factor 2A	LIG_APCC_ABBA_1	107:112	LTPHTE	APC,CDC20,FZR1	0.9741	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons