DegronMD

Uniprot ID: Q02078

Source protein: Myocyte-specific enhancer factor 2A

Source gene: MEF2A

Class: DEG_ODPH_VHL_1

Location: 131:144

E3 ligase: VHL

DEGRON score: 0.8157

ASA_SCORE: 81.0929

COIL: 0.8872

CONS_SCORE: 0.3226

DSS_SCORE: 0.4578

HELIX: 0.0866

FCONS_SCORE: 1.0192

RIG_SCORE: 0.6826

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G136C	DO229035	LICA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.76
p.G137V	DO229045	LICA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.7532
p.I131T	TCGA-2W-A8YY	CESC	TCGA	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.7078
p.I131T	DO223732	CESC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.7078
p.D143N	DO41871	UCEC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.6932
p.M142I	DO229019	LICA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.6507
p.M142L	TCGA-CD-A4MG	STAD	TCGA	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.5999
p.V144A	TCGA-F4-6854	COAD	TCGA	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.5825
p.V144A	DO8071	COAD	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.5825
p.K130T	TCGA-B5-A1MR	UCEC	TCGA	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.3056
p.K130T	DO41758	UCEC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.3056
p.K130N	DO23220	LINC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.3056
p.K130N	DO23146	LINC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.3056
p.G129C	DO46657	PAAD	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.2778
p.R127Q	TCGA-EO-A22R	UCEC	TCGA	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.2222
p.R127Q	DO222983	BTCA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.2222
p.R127Q	DO42713	UCEC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.2222
p.R127W	SIDM01293	Colorectal Carcinoma	GDSC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.2222
p.R127W	ACH-000990	Endometrial/Uterine Cancer	CCLE	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.2222
p.G149A	DO219083	BLCA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.1944
p.P126S	DO26536	LUSC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.1944
p.P126S	DO220872	MELA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.1944
p.P126S	DO37406	SKCM	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.1944
p.P126S	DO38153	SKCM	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.1944
p.M125V	SIDM01520	Oral Cavity Carcinoma	GDSC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.1667

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Drug responses associated with MEF2A mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of IAPGLPPQNFSMSV

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02078	Myocyte-specific enhancer factor 2A	DEG_ODPH_VHL_1	131:144	IAPGLPPQNFSMSV	VHL	0.8157	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPGLPPQNFSMSV

Degron related mutations and impact score

Drug responses associated with MEF2A mutations

All proteins holding degron of IAPGLPPQNFSMSV