DegronMD

Uniprot ID: Q02078

Source protein: Myocyte-specific enhancer factor 2A

Source gene: MEF2A

Class: DEG_ODPH_VHL_1

Location: 131:144

E3 ligase: VHL

DEGRON score: 0.8157

ASA_SCORE: 81.0929

COIL: 0.8872

CONS_SCORE: 0.3226

DSS_SCORE: 0.4578

HELIX: 0.0866

FCONS_SCORE: 1.0192

RIG_SCORE: 0.6826

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I131T	TCGA-2W-A8YY	CESC	TCGA	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.7078
p.I131T	DO223732	CESC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.7078
p.K130T	TCGA-B5-A1MR	UCEC	TCGA	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.3056
p.K130T	DO41758	UCEC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.3056
p.M142L	TCGA-CD-A4MG	STAD	TCGA	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.5999
p.P151S	TCGA-EB-A51B	SKCM	TCGA	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.1389
p.R127Q	TCGA-EO-A22R	UCEC	TCGA	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.2222
p.R127Q	DO222983	BTCA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.2222
p.R127Q	DO42713	UCEC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.2222
p.V144A	TCGA-F4-6854	COAD	TCGA	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.5825
p.V144A	DO8071	COAD	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.5825
p.G149A	DO219083	BLCA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.1944
p.F124L	DO9876	COAD	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.1389
p.D121V	DO52054	HNSC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.0556
p.M142I	DO229019	LICA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.6507
p.G136C	DO229035	LICA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.76
p.G137V	DO229045	LICA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.7532
p.K130N	DO23220	LINC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.3056
p.K130N	DO23146	LINC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.3056
p.P126S	DO26536	LUSC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.1944
p.P126S	DO220872	MELA	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.1944
p.P126S	DO37406	SKCM	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.1944
p.P126S	DO38153	SKCM	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.1944
p.G129C	DO46657	PAAD	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.2778
p.S122F	DO47747	STAD	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.0833
p.D143N	DO41871	UCEC	ICGC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.6932
p.R127W	SIDM01293	Colorectal Carcinoma	GDSC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.2222
p.R127W	ACH-000990	Endometrial/Uterine Cancer	CCLE	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.2222
p.M125V	SIDM01520	Oral Cavity Carcinoma	GDSC	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.1667
p.M125V	ACH-000503	Head and Neck Cancer	CCLE	IAPGLPPQNFSMSV	DEG_ODPH_VHL_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPGLPPQNFSMSV

Degron related mutations and impact score

Drug responses associated with MEF2A mutations

All proteins holding degron of IAPGLPPQNFSMSV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02078	Myocyte-specific enhancer factor 2A	DEG_ODPH_VHL_1	131:144	IAPGLPPQNFSMSV	VHL	0.8157	More...