DegronMD - Q9C0A1(ZFHX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E948D	TCGA-A5-A2K5	UCEC	TCGA	PVTPLAE	DEG_SCF_FBW7_2	937:943	Mutation rewiring degron network	0.1944
p.E948D	DO41379	UCEC	ICGC	PVTPLAE	DEG_SCF_FBW7_2	937:943	Mutation rewiring degron network	0.1944
p.S2567Y	TCGA-AP-A1E0	UCEC	TCGA	PKTTT	DEG_SPOP_SBC_1	2561:2565	Mutation rewiring degron network	0.2778
p.S2567Y	DO43154	UCEC	ICGC	PKTTT	DEG_SPOP_SBC_1	2561:2565	Mutation rewiring degron network	0.2778
p.G1585W	TCGA-B5-A1MX	UCEC	TCGA	SRGNLPPLV	DEG_APCC_DBOX_1	1583:1591	Mutation altering degron motif	0.6714
p.G1585W	DO41999	UCEC	ICGC	SRGNLPPLV	DEG_APCC_DBOX_1	1583:1591	Mutation altering degron motif	0.6714
p.R420C	TCGA-D1-A167	UCEC	TCGA	DDYTPAP	CBL_PTK	423:429	Mutation rewiring degron network	0.25
p.R420C	DO40978	UCEC	ICGC	DDYTPAP	CBL_PTK	423:429	Mutation rewiring degron network	0.25
p.P429S	TCGA-EK-A2PG	CESC	TCGA	DDYTPAP	CBL_PTK	423:429	Mutation altering degron motif	0.6752
p.P429S	DO49939	CESC	ICGC	DDYTPAP	CBL_PTK	423:429	Mutation altering degron motif	0.6752
p.L2572V	TCGA-EO-A22X	UCEC	TCGA	PKTTT	DEG_SPOP_SBC_1	2561:2565	Mutation rewiring degron network	0.1389
p.L2572V	DO43907	UCEC	ICGC	PKTTT	DEG_SPOP_SBC_1	2561:2565	Mutation rewiring degron network	0.1389
p.T47I	TCGA-EY-A215	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	43:47	Mutation altering degron motif	0.7078
p.T47I	DO42665	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	43:47	Mutation altering degron motif	0.7078
p.P1937H	TCGA-EY-A5W2	UCEC	TCGA	STPGGVPSP	DEG_COP1_1	1919:1927	Mutation rewiring degron network	0.0556
p.P1937H	DO48177	UCEC	ICGC	STPGGVPSP	DEG_COP1_1	1919:1927	Mutation rewiring degron network	0.0556
p.Q952R	TCGA-LN-A4A4	ESCA	TCGA	PVTPLAE	DEG_SCF_FBW7_2	937:943	Mutation rewiring degron network	0.0833
p.G434D	DO234460	BPLL	ICGC	DDYTPAP	CBL_PTK	423:429	Mutation rewiring degron network	0.1944
p.Q952H	DO1016	BRCA	ICGC	PVTPLAE	DEG_SCF_FBW7_2	937:943	Mutation rewiring degron network	0.0833
p.D35N	DO49009	CESC	ICGC	AASST	DEG_SPOP_SBC_1	43:47	Mutation rewiring degron network	0.1111
p.D40G	DO222793	COCA	ICGC	AASST	DEG_SPOP_SBC_1	43:47	Mutation rewiring degron network	0.25
p.R1595C	DO228696	EOPC	ICGC	SRGNLPPLV	DEG_APCC_DBOX_1	1583:1591	Mutation rewiring degron network	0.2222
p.G1594D	DO233262	GACA	ICGC	SRGNLPPLV	DEG_APCC_DBOX_1	1583:1591	Mutation rewiring degron network	0.25
p.A428D	DO228952	LICA	ICGC	DDYTPAP	CBL_PTK	423:429	Mutation altering degron motif	0.6682
p.D424E	DO228978	LICA	ICGC	DDYTPAP	CBL_PTK	423:429	Mutation altering degron motif	0.5647
p.T932N	DO229028	LICA	ICGC	PVTPLAE	DEG_SCF_FBW7_2	937:943	Mutation rewiring degron network	0.1944
p.H2556Q	DO229031	LICA	ICGC	PKTTT	DEG_SPOP_SBC_1	2561:2565	Mutation rewiring degron network	0.1944
p.P944T	DO229031	LICA	ICGC	PVTPLAE	DEG_SCF_FBW7_2	937:943	Mutation rewiring degron network	0.3056
p.T2320N	DO229037	LICA	ICGC	PTSSS	DEG_SPOP_SBC_1	2319:2323	Mutation altering degron motif	0.5944
p.P2555T	DO229037	LICA	ICGC	PKTTT	DEG_SPOP_SBC_1	2561:2565	Mutation rewiring degron network	0.1667
p.A431D	DO229045	LICA	ICGC	DDYTPAP	CBL_PTK	423:429	Mutation rewiring degron network	0.2778
p.A422D	DO229008	LICA	ICGC	DDYTPAP	CBL_PTK	423:429	Mutation rewiring degron network	0.3056
p.G928R	DO23468	LINC	ICGC	PVTPLAE	DEG_SCF_FBW7_2	937:943	Mutation rewiring degron network	0.0833
p.N953D	DO50805	LIRI	ICGC	PVTPLAE	DEG_SCF_FBW7_2	937:943	Mutation rewiring degron network	0.0556
p.R1918Q	DO222702	MELA	ICGC	STPGGVPSP	DEG_COP1_1	1919:1927	Mutation rewiring degron network	0.3056
p.T2564M	DO48938	PBCA	ICGC	PKTTT	DEG_SPOP_SBC_1	2561:2565	Mutation altering degron motif	0.7423
p.T2564M	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PKTTT	DEG_SPOP_SBC_1	2561:2565	Mutation altering degron motif	0.7423
p.T2564M	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PKTTT	DEG_SPOP_SBC_1	2561:2565	Mutation altering degron motif	0.7423
p.T1920P	DO229491	SKCA	ICGC	STPGGVPSP	DEG_COP1_1	1919:1927	Mutation altering degron motif	0.7031
p.S2559P	SIDM00845	Burkitt's Lymphoma	GDSC	PKTTT	DEG_SPOP_SBC_1	2561:2565	Mutation rewiring degron network	0.2778
p.S2559P	ACH-001067	Brain Cancer	CCLE	PKTTT	DEG_SPOP_SBC_1	2561:2565	Mutation rewiring degron network	0.2778
p.V1819L	SIDM00947	Glioblastoma	GDSC	LLVFGE	LIG_APCC_ABBA_1	1809:1814	Mutation rewiring degron network	0.1944
p.V1819L	ACH-000244	Brain Cancer	CCLE	LLVFGE	LIG_APCC_ABBA_1	1809:1814	Mutation rewiring degron network	0.1944
p.V1819L	DK-MG	central nervous system	COSMIC	LLVFGE	LIG_APCC_ABBA_1	1809:1814	Mutation rewiring degron network	0.1944
p.V1591M	SIDM00883	Non-Cancerous	GDSC	SRGNLPPLV	DEG_APCC_DBOX_1	1583:1591	Mutation altering degron motif	0.6097
p.V1591M	SIDM00884	Breast Carcinoma	GDSC	SRGNLPPLV	DEG_APCC_DBOX_1	1583:1591	Mutation altering degron motif	0.6097
p.K935E	ACH-001991	Primary	CCLE	PVTPLAE	DEG_SCF_FBW7_2	937:943	Mutation rewiring degron network	0.2778
p.T426P	HEC-1	endometrium	COSMIC	DDYTPAP	CBL_PTK	423:429	Mutation altering degron motif	0.7031

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZFHX2

UniProt ID: Q9C0A1

Entrez ID: 85446

Protein name: Zinc finger homeobox protein 2 (Zinc finger homeodomain protein 2) (ZFH-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZFHX2 in