DegronMD

Uniprot ID: Q9C0A1

Source protein: Zinc finger homeobox protein 2

Source gene: ZFHX2

Class: DEG_APCC_DBOX_1

Location: 1583:1591

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9423

ASA_SCORE: 91.4889

COIL: 0.9178

CONS_SCORE: 0.2297

DSS_SCORE: 0.5932

HELIX: 0.0467

FCONS_SCORE: 0.5052

RIG_SCORE: 0.6369

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1585W	TCGA-B5-A1MX	UCEC	TCGA	SRGNLPPLV	DEG_APCC_DBOX_1	0.6714
p.G1585W	DO41999	UCEC	ICGC	SRGNLPPLV	DEG_APCC_DBOX_1	0.6714
p.R1595C	DO228696	EOPC	ICGC	SRGNLPPLV	DEG_APCC_DBOX_1	0.2222
p.G1594D	DO233262	GACA	ICGC	SRGNLPPLV	DEG_APCC_DBOX_1	0.25
p.V1591M	SIDM00883	Non-Cancerous	GDSC	SRGNLPPLV	DEG_APCC_DBOX_1	0.6097
p.V1591M	SIDM00884	Breast Carcinoma	GDSC	SRGNLPPLV	DEG_APCC_DBOX_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0A1	Zinc finger homeobox protein 2	DEG_APCC_DBOX_1	1583:1591	SRGNLPPLV	APC,CDC20,FZR1	0.9423	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons