DegronMD

Uniprot ID: Q9C0A1

Source protein: Zinc finger homeobox protein 2

Source gene: ZFHX2

Class: DEG_SCF_FBW7_2

Location: 937:943

E3 ligase: FBXW7

DEGRON score: 0.8669

ASA_SCORE: 95.6143

COIL: 0.909

CONS_SCORE: 0.3225

DSS_SCORE: 0.7859

HELIX: 0.042

FCONS_SCORE: 0.9078

RIG_SCORE: 0.622

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E948D	TCGA-A5-A2K5	UCEC	TCGA	PVTPLAE	DEG_SCF_FBW7_2	0.1944
p.E948D	DO41379	UCEC	ICGC	PVTPLAE	DEG_SCF_FBW7_2	0.1944
p.Q952R	TCGA-LN-A4A4	ESCA	TCGA	PVTPLAE	DEG_SCF_FBW7_2	0.0833
p.Q952H	DO1016	BRCA	ICGC	PVTPLAE	DEG_SCF_FBW7_2	0.0833
p.T932N	DO229028	LICA	ICGC	PVTPLAE	DEG_SCF_FBW7_2	0.1944
p.P944T	DO229031	LICA	ICGC	PVTPLAE	DEG_SCF_FBW7_2	0.3056
p.G928R	DO23468	LINC	ICGC	PVTPLAE	DEG_SCF_FBW7_2	0.0833
p.N953D	DO50805	LIRI	ICGC	PVTPLAE	DEG_SCF_FBW7_2	0.0556
p.K935E	ACH-001991	Primary	CCLE	PVTPLAE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0A1	Zinc finger homeobox protein 2	DEG_SCF_FBW7_2	937:943	PVTPLAE	FBXW7	0.8669	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons