DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LLVFGE
Uniprot ID:
Q9C0A1
Source protein:
Zinc finger homeobox protein 2
Source gene:
ZFHX2
Class:
LIG_APCC_ABBA_1
Location:
1809:1814
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9351
ASA_SCORE:
85.15
COIL:
0.7687
CONS_SCORE:
0.5132
DSS_SCORE:
0.2721
HELIX:
0.1398
FCONS_SCORE:
1.1988
RIG_SCORE:
0.7821
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V1819L
SIDM00947
Glioblastoma
GDSC
LLVFGE
LIG_APCC_ABBA_1
0.1944
p.V1819L
ACH-000244
Brain Cancer
CCLE
LLVFGE
LIG_APCC_ABBA_1
0.1944
p.V1819L
DK-MG
central_nervous_system
COSMIC
LLVFGE
LIG_APCC_ABBA_1
0.1944
Drug responses associated with ZFHX2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LLVFGE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9C0A1
Zinc finger homeobox protein 2
LIG_APCC_ABBA_1
1809:1814
LLVFGE
APC,CDC20,FZR1
0.9351
More...