DegronMD

Uniprot ID: Q9C0A1

Source protein: Zinc finger homeobox protein 2

Source gene: ZFHX2

Class: DEG_SPOP_SBC_1

Location: 2561:2565

E3 ligase: SPOP

DEGRON score: 0.9848

ASA_SCORE: 87.28

COIL: 0.8488

CONS_SCORE: 0.4677

DSS_SCORE: 0.6235

HELIX: 0.0696

FCONS_SCORE: 1.3203

RIG_SCORE: 0.6828

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2567Y	TCGA-AP-A1E0	UCEC	TCGA	PKTTT	DEG_SPOP_SBC_1	0.2778
p.S2567Y	DO43154	UCEC	ICGC	PKTTT	DEG_SPOP_SBC_1	0.2778
p.L2572V	TCGA-EO-A22X	UCEC	TCGA	PKTTT	DEG_SPOP_SBC_1	0.1389
p.L2572V	DO43907	UCEC	ICGC	PKTTT	DEG_SPOP_SBC_1	0.1389
p.H2556Q	DO229031	LICA	ICGC	PKTTT	DEG_SPOP_SBC_1	0.1944
p.P2555T	DO229037	LICA	ICGC	PKTTT	DEG_SPOP_SBC_1	0.1667
p.T2564M	DO48938	PBCA	ICGC	PKTTT	DEG_SPOP_SBC_1	0.7423
p.T2564M	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PKTTT	DEG_SPOP_SBC_1	0.7423
p.T2564M	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PKTTT	DEG_SPOP_SBC_1	0.7423
p.S2559P	SIDM00845	Burkitt's Lymphoma	GDSC	PKTTT	DEG_SPOP_SBC_1	0.2778
p.S2559P	ACH-001067	Brain Cancer	CCLE	PKTTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0VDD8	Dynein axonemal heavy chain 14	DEG_SPOP_SBC_1	3119:3123	PKTTT	SPOP	0.7354	More...
Q9C0A1	Zinc finger homeobox protein 2	DEG_SPOP_SBC_1	2561:2565	PKTTT	SPOP	0.9848	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons