DegronMD

Uniprot ID: Q0VDD8

Source protein: Dynein axonemal heavy chain 14

Source gene: DNAH14

Class: DEG_SPOP_SBC_1

Location: 3119:3123

E3 ligase: SPOP

DEGRON score: 0.7354

ASA_SCORE: 66.06

COIL: 0.6792

CONS_SCORE: 0.5208

DSS_SCORE: 0.331

HELIX: 0.1868

FCONS_SCORE: 1.6866

RIG_SCORE: 0.7913

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3121N	TCGA-BS-A0UF	UCEC	TCGA	PKTTT	DEG_SPOP_SBC_1	0.7055
p.N3130T	DO50442	ESAD	ICGC	PKTTT	DEG_SPOP_SBC_1	0.1389
p.G3119C	DO229029	LICA	ICGC	PKTTT	DEG_SPOP_SBC_1	0.76
p.G3119V	DO229028	LICA	ICGC	PKTTT	DEG_SPOP_SBC_1	0.7532
p.A3126V	DO43755	UCEC	ICGC	PKTTT	DEG_SPOP_SBC_1	0.25
p.Q3129K	SIDM00193	Colorectal Carcinoma	GDSC	PKTTT	DEG_SPOP_SBC_1	0.1667
p.Q3122R	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKTTT	DEG_SPOP_SBC_1	0.7329
p.M3127T	ACH-000788	Skin Cancer	CCLE	PKTTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0VDD8	Dynein axonemal heavy chain 14	DEG_SPOP_SBC_1	3119:3123	PKTTT	SPOP	0.7354	More...
Q9C0A1	Zinc finger homeobox protein 2	DEG_SPOP_SBC_1	2561:2565	PKTTT	SPOP	0.9848	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons