DegronMD - Q0VDD8(DNAH14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T2943K	TCGA-2H-A9GJ	ESCA	TCGA	LISTPFSS	DEG_SCF_FBW7_1	2927:2934	Mutation rewiring degron network	0.0833
p.T3121N	TCGA-BS-A0UF	UCEC	TCGA	PKTTT	DEG_SPOP_SBC_1	3119:3123	Mutation altering degron motif	0.7055
p.S2926Y	TCGA-BS-A0UV	UCEC	TCGA	LISTPFSS	DEG_SCF_FBW7_1	2927:2934	Mutation rewiring degron network	0.3056
p.L3064R	TCGA-EY-A1GD	UCEC	TCGA	ARTPLILIQ	DEG_APCC_DBOX_1	3058:3066	Mutation altering degron motif	0.7316
p.L3061F	DO51989	CLLE	ICGC	ARTPLILIQ	DEG_APCC_DBOX_1	3058:3066	Mutation altering degron motif	0.6981
p.D3393E	DO230334	COCA	ICGC	FGLFIE	LIG_APCC_ABBA_1	3399:3404	Mutation rewiring degron network	0.1667
p.D3393E	DO229010	COCA	ICGC	FGLFIE	LIG_APCC_ABBA_1	3399:3404	Mutation rewiring degron network	0.1667
p.D3393E	DO229013	COCA	ICGC	FGLFIE	LIG_APCC_ABBA_1	3399:3404	Mutation rewiring degron network	0.1667
p.D3393E	DO229016	COCA	ICGC	FGLFIE	LIG_APCC_ABBA_1	3399:3404	Mutation rewiring degron network	0.1667
p.D3393E	DO229003	COCA	ICGC	FGLFIE	LIG_APCC_ABBA_1	3399:3404	Mutation rewiring degron network	0.1667
p.D3393E	DO229005	COCA	ICGC	FGLFIE	LIG_APCC_ABBA_1	3399:3404	Mutation rewiring degron network	0.1667
p.D3393E	DO229346	LAML	ICGC	FGLFIE	LIG_APCC_ABBA_1	3399:3404	Mutation rewiring degron network	0.1667
p.D3393E	DO229505	LAML	ICGC	FGLFIE	LIG_APCC_ABBA_1	3399:3404	Mutation rewiring degron network	0.1667
p.N3130T	DO50442	ESAD	ICGC	PKTTT	DEG_SPOP_SBC_1	3119:3123	Mutation rewiring degron network	0.1389
p.A3097V	DO234187	ESAD	ICGC	LGIHPE	LIG_APCC_ABBA_1	3092:3097	Mutation altering degron motif	0.6936
p.E2932D	DO228976	LICA	ICGC	LISTPFSS	DEG_SCF_FBW7_1	2927:2934	Mutation altering degron motif	0.6758
p.M2929I	DO229019	LICA	ICGC	LISTPFSS	DEG_SCF_FBW7_1	2927:2934	Mutation altering degron motif	0.7618
p.M2929I	DO43891	UCEC	ICGC	LISTPFSS	DEG_SCF_FBW7_1	2927:2934	Mutation altering degron motif	0.7618
p.G3119C	DO229029	LICA	ICGC	PKTTT	DEG_SPOP_SBC_1	3119:3123	Mutation altering degron motif	0.76
p.G3119V	DO229028	LICA	ICGC	PKTTT	DEG_SPOP_SBC_1	3119:3123	Mutation altering degron motif	0.7532
p.I3062V	DO52170	LIHC	ICGC	ARTPLILIQ	DEG_APCC_DBOX_1	3058:3066	Mutation altering degron motif	0.7076
p.S3092L	DO228376	MALY	ICGC	LGIHPE	LIG_APCC_ABBA_1	3092:3097	Mutation altering degron motif	0.7667
p.S3092L	DO229459	SKCA	ICGC	LGIHPE	LIG_APCC_ABBA_1	3092:3097	Mutation altering degron motif	0.7667
p.S3092L	DO42713	UCEC	ICGC	LGIHPE	LIG_APCC_ABBA_1	3092:3097	Mutation altering degron motif	0.7667
p.S3092L	SIDM00118	Colorectal Carcinoma	GDSC	LGIHPE	LIG_APCC_ABBA_1	3092:3097	Mutation altering degron motif	0.7667
p.S3092L	HCC2998	large intestine	COSMIC	LGIHPE	LIG_APCC_ABBA_1	3092:3097	Mutation altering degron motif	0.7667
p.Q2939H	DO222599	MELA	ICGC	LISTPFSS	DEG_SCF_FBW7_1	2927:2934	Mutation rewiring degron network	0.1944
p.A3107P	DO27887	ORCA	ICGC	LGIHPE	LIG_APCC_ABBA_1	3092:3097	Mutation rewiring degron network	0.0556
p.F3086L	DO233558	PRAD	ICGC	LGIHPE	LIG_APCC_ABBA_1	3092:3097	Mutation rewiring degron network	0.1667
p.S3095F	DO229453	SKCA	ICGC	LGIHPE	LIG_APCC_ABBA_1	3092:3097	Mutation altering degron motif	0.7982
p.L3052I	DO219773	UCEC	ICGC	ARTPLILIQ	DEG_APCC_DBOX_1	3058:3066	Mutation rewiring degron network	0.1667
p.K3066N	DO40996	UCEC	ICGC	ARTPLILIQ	DEG_APCC_DBOX_1	3058:3066	Mutation altering degron motif	0.6918
p.L3061W	DO41020	UCEC	ICGC	ARTPLILIQ	DEG_APCC_DBOX_1	3058:3066	Mutation altering degron motif	0.7015
p.L2936I	DO43907	UCEC	ICGC	LISTPFSS	DEG_SCF_FBW7_1	2927:2934	Mutation rewiring degron network	0.2778
p.A3126V	DO43755	UCEC	ICGC	PKTTT	DEG_SPOP_SBC_1	3119:3123	Mutation rewiring degron network	0.25
p.I3069M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ARTPLILIQ	DEG_APCC_DBOX_1	3058:3066	Mutation rewiring degron network	0.25
p.I3069M	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ARTPLILIQ	DEG_APCC_DBOX_1	3058:3066	Mutation rewiring degron network	0.25
p.Q3129K	SIDM00193	Colorectal Carcinoma	GDSC	PKTTT	DEG_SPOP_SBC_1	3119:3123	Mutation rewiring degron network	0.1667
p.E3054A	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	ARTPLILIQ	DEG_APCC_DBOX_1	3058:3066	Mutation substituting flanking lysine	0.3333
p.E3054A	LCLC-103H	lung	COSMIC	ARTPLILIQ	DEG_APCC_DBOX_1	3058:3066	Mutation substituting flanking lysine	0.3333
p.V3073I	SIDM00178	Melanoma	GDSC	ARTPLILIQ	DEG_APCC_DBOX_1	3058:3066	Mutation rewiring degron network	0.1389
p.D3065Y	SIDM01133	Other Solid Cancers	GDSC	ARTPLILIQ	DEG_APCC_DBOX_1	3058:3066	Mutation altering degron motif	0.7325
p.D3065Y	NCI-H835	lung	COSMIC	ARTPLILIQ	DEG_APCC_DBOX_1	3058:3066	Mutation altering degron motif	0.7325
p.Q3122R	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKTTT	DEG_SPOP_SBC_1	3119:3123	Mutation altering degron motif	0.7329
p.P2931T	ACH-000146	Leukemia	CCLE	LISTPFSS	DEG_SCF_FBW7_1	2927:2934	Mutation altering degron motif	0.7031
p.A2923S	ACH-000206	Lymphoma	CCLE	LISTPFSS	DEG_SCF_FBW7_1	2927:2934	Mutation rewiring degron network	0.2222
p.M3127T	ACH-000788	Skin Cancer	CCLE	PKTTT	DEG_SPOP_SBC_1	3119:3123	Mutation rewiring degron network	0.2222
p.A3058D	ACH-000990	Endometrial/Uterine Cancer	CCLE	ARTPLILIQ	DEG_APCC_DBOX_1	3058:3066	Mutation altering degron motif	0.6682
p.E3411V	ACH-001685	Lymphoma	CCLE	FGLFIE	LIG_APCC_ABBA_1	3399:3404	Mutation rewiring degron network	0.1389
p.K3054E	ACH-002062	Lymphoma	CCLE	ARTPLILIQ	DEG_APCC_DBOX_1	3058:3066	Mutation substituting flanking lysine	0.3333
p.R3410C	ACH-002160	Bone Cancer	CCLE	FGLFIE	LIG_APCC_ABBA_1	3399:3404	Mutation rewiring degron network	0.1667
p.R3410C	MC-IXC	autonomic ganglia	COSMIC	FGLFIE	LIG_APCC_ABBA_1	3399:3404	Mutation rewiring degron network	0.1667
p.A3107V	Sarc9371	bone	COSMIC	LGIHPE	LIG_APCC_ABBA_1	3092:3097	Mutation rewiring degron network	0.0556
p.L3052F	Sarc9371	bone	COSMIC	ARTPLILIQ	DEG_APCC_DBOX_1	3058:3066	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAH14

UniProt ID: Q0VDD8

Entrez ID: 127602

Protein name: Dynein axonemal heavy chain 14 (Axonemal beta dynein heavy chain 14) (Ciliary dynein heavy chain 14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNAH14 in