DegronMD

Uniprot ID: Q0VDD8

Source protein: Dynein axonemal heavy chain 14

Source gene: DNAH14

Class: LIG_APCC_ABBA_1

Location: 3399:3404

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.655

ASA_SCORE: 15.1833

COIL: 0.3522

CONS_SCORE: 0.518

DSS_SCORE: 0.0479

HELIX: 0.0192

FCONS_SCORE: 1.4329

RIG_SCORE: 0.9189

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D3393E	DO230334	COCA	ICGC	FGLFIE	LIG_APCC_ABBA_1	0.1667
p.D3393E	DO229010	COCA	ICGC	FGLFIE	LIG_APCC_ABBA_1	0.1667
p.D3393E	DO229013	COCA	ICGC	FGLFIE	LIG_APCC_ABBA_1	0.1667
p.D3393E	DO229016	COCA	ICGC	FGLFIE	LIG_APCC_ABBA_1	0.1667
p.D3393E	DO229003	COCA	ICGC	FGLFIE	LIG_APCC_ABBA_1	0.1667
p.D3393E	DO229005	COCA	ICGC	FGLFIE	LIG_APCC_ABBA_1	0.1667
p.D3393E	DO229346	LAML	ICGC	FGLFIE	LIG_APCC_ABBA_1	0.1667
p.D3393E	DO229505	LAML	ICGC	FGLFIE	LIG_APCC_ABBA_1	0.1667
p.E3411V	ACH-001685	Lymphoma	CCLE	FGLFIE	LIG_APCC_ABBA_1	0.1389
p.R3410C	ACH-002160	Bone Cancer	CCLE	FGLFIE	LIG_APCC_ABBA_1	0.1667
p.R3410C	MC-IXC	autonomic_ganglia	COSMIC	FGLFIE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0VDD8	Dynein axonemal heavy chain 14	LIG_APCC_ABBA_1	3399:3404	FGLFIE	APC,CDC20,FZR1	0.655	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons