DegronMD

Uniprot ID: Q0VDD8

Source protein: Dynein axonemal heavy chain 14

Source gene: DNAH14

Class: DEG_SCF_FBW7_1

Location: 2927:2934

E3 ligase: FBXW7

DEGRON score: 0.9493

ASA_SCORE: 57.6

COIL: 0.8383

CONS_SCORE: 0.1325

DSS_SCORE: 0.266

HELIX: 0.0764

FCONS_SCORE: 2.1705

RIG_SCORE: 0.7393

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2943K	TCGA-2H-A9GJ	ESCA	TCGA	LISTPFSS	DEG_SCF_FBW7_1	0.0833
p.S2926Y	TCGA-BS-A0UV	UCEC	TCGA	LISTPFSS	DEG_SCF_FBW7_1	0.3056
p.E2932D	DO228976	LICA	ICGC	LISTPFSS	DEG_SCF_FBW7_1	0.6758
p.M2929I	DO229019	LICA	ICGC	LISTPFSS	DEG_SCF_FBW7_1	0.7618
p.M2929I	DO43891	UCEC	ICGC	LISTPFSS	DEG_SCF_FBW7_1	0.7618
p.Q2939H	DO222599	MELA	ICGC	LISTPFSS	DEG_SCF_FBW7_1	0.1944
p.L2936I	DO43907	UCEC	ICGC	LISTPFSS	DEG_SCF_FBW7_1	0.2778
p.P2931T	ACH-000146	Leukemia	CCLE	LISTPFSS	DEG_SCF_FBW7_1	0.7031
p.A2923S	ACH-000206	Lymphoma	CCLE	LISTPFSS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0VDD8	Dynein axonemal heavy chain 14	DEG_SCF_FBW7_1	2927:2934	LISTPFSS	FBXW7	0.9493	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons