DegronMD

Uniprot ID: Q0VDD8

Source protein: Dynein axonemal heavy chain 14

Source gene: DNAH14

Class: DEG_APCC_DBOX_1

Location: 3058:3066

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5597

ASA_SCORE: 40.1

COIL: 0.5062

CONS_SCORE: 0.6603

DSS_SCORE: 0.2871

HELIX: 0.0287

FCONS_SCORE: 2.1385

RIG_SCORE: 0.8264

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L3064R	TCGA-EY-A1GD	UCEC	TCGA	ARTPLILIQ	DEG_APCC_DBOX_1	0.7316
p.L3061F	DO51989	CLLE	ICGC	ARTPLILIQ	DEG_APCC_DBOX_1	0.6981
p.I3062V	DO52170	LIHC	ICGC	ARTPLILIQ	DEG_APCC_DBOX_1	0.7076
p.L3052I	DO219773	UCEC	ICGC	ARTPLILIQ	DEG_APCC_DBOX_1	0.1667
p.K3066N	DO40996	UCEC	ICGC	ARTPLILIQ	DEG_APCC_DBOX_1	0.6918
p.L3061W	DO41020	UCEC	ICGC	ARTPLILIQ	DEG_APCC_DBOX_1	0.7015
p.I3069M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ARTPLILIQ	DEG_APCC_DBOX_1	0.25
p.I3069M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ARTPLILIQ	DEG_APCC_DBOX_1	0.25
p.E3054A	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	ARTPLILIQ	DEG_APCC_DBOX_1	0.3333
p.E3054A	LCLC-103H	lung	COSMIC	ARTPLILIQ	DEG_APCC_DBOX_1	0.3333
p.V3073I	SIDM00178	Melanoma	GDSC	ARTPLILIQ	DEG_APCC_DBOX_1	0.1389
p.D3065Y	SIDM01133	Other Solid Cancers	GDSC	ARTPLILIQ	DEG_APCC_DBOX_1	0.7325
p.D3065Y	NCI-H835	lung	COSMIC	ARTPLILIQ	DEG_APCC_DBOX_1	0.7325
p.A3058D	ACH-000990	Endometrial/Uterine Cancer	CCLE	ARTPLILIQ	DEG_APCC_DBOX_1	0.6682
p.K3054E	ACH-002062	Lymphoma	CCLE	ARTPLILIQ	DEG_APCC_DBOX_1	0.3333
p.L3052F	Sarc9371	bone	COSMIC	ARTPLILIQ	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0VDD8	Dynein axonemal heavy chain 14	DEG_APCC_DBOX_1	3058:3066	ARTPLILIQ	APC,CDC20,FZR1	0.5597	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons