DegronMD

Uniprot ID: Q0VDD8

Source protein: Dynein axonemal heavy chain 14

Source gene: DNAH14

Class: LIG_APCC_ABBA_1

Location: 3092:3097

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5474

ASA_SCORE: 31.55

COIL: 0.4838

CONS_SCORE: 0.3528

DSS_SCORE: 0.302

HELIX: 0.2352

FCONS_SCORE: 1.4616

RIG_SCORE: 0.7922

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3097V	DO234187	ESAD	ICGC	LGIHPE	LIG_APCC_ABBA_1	0.6936
p.S3092L	DO228376	MALY	ICGC	LGIHPE	LIG_APCC_ABBA_1	0.7667
p.S3092L	DO229459	SKCA	ICGC	LGIHPE	LIG_APCC_ABBA_1	0.7667
p.S3092L	DO42713	UCEC	ICGC	LGIHPE	LIG_APCC_ABBA_1	0.7667
p.S3092L	SIDM00118	Colorectal Carcinoma	GDSC	LGIHPE	LIG_APCC_ABBA_1	0.7667
p.S3092L	HCC2998	large_intestine	COSMIC	LGIHPE	LIG_APCC_ABBA_1	0.7667
p.A3107P	DO27887	ORCA	ICGC	LGIHPE	LIG_APCC_ABBA_1	0.0556
p.F3086L	DO233558	PRAD	ICGC	LGIHPE	LIG_APCC_ABBA_1	0.1667
p.S3095F	DO229453	SKCA	ICGC	LGIHPE	LIG_APCC_ABBA_1	0.7982
p.A3107V	Sarc9371	bone	COSMIC	LGIHPE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0VDD8	Dynein axonemal heavy chain 14	LIG_APCC_ABBA_1	3092:3097	LGIHPE	APC,CDC20,FZR1	0.5474	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons