DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DDYTPAP
Uniprot ID:
Q9C0A1
Source protein:
Zinc finger homeobox protein 2
Source gene:
ZFHX2
Class:
CBL_PTK
Location:
423:429
E3 ligase:
CBL
DEGRON score:
0.9901
ASA_SCORE:
72.1429
COIL:
0.714
CONS_SCORE:
0.3959
DSS_SCORE:
0.5185
HELIX:
0.1543
FCONS_SCORE:
1.0242
RIG_SCORE:
0.7265
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R420C
TCGA-D1-A167
UCEC
TCGA
DDYTPAP
CBL_PTK
0.25
p.R420C
DO40978
UCEC
ICGC
DDYTPAP
CBL_PTK
0.25
p.P429S
TCGA-EK-A2PG
CESC
TCGA
DDYTPAP
CBL_PTK
0.6752
p.P429S
DO49939
CESC
ICGC
DDYTPAP
CBL_PTK
0.6752
p.G434D
DO234460
BPLL
ICGC
DDYTPAP
CBL_PTK
0.1944
p.A428D
DO228952
LICA
ICGC
DDYTPAP
CBL_PTK
0.6682
p.D424E
DO228978
LICA
ICGC
DDYTPAP
CBL_PTK
0.5647
p.A431D
DO229045
LICA
ICGC
DDYTPAP
CBL_PTK
0.2778
p.A422D
DO229008
LICA
ICGC
DDYTPAP
CBL_PTK
0.3056
p.T426P
HEC-1
endometrium
COSMIC
DDYTPAP
CBL_PTK
0.7031
Drug responses associated with ZFHX2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DDYTPAP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9C0A1
Zinc finger homeobox protein 2
CBL_PTK
423:429
DDYTPAP
CBL
0.9901
More...
