DegronMD

Uniprot ID: Q9BZZ2

Source protein: Sialoadhesin

Source gene: SIGLEC1

Class: DEG_SPOP_SBC_1

Location: 564:568

E3 ligase: SPOP

DEGRON score: 0.8123

ASA_SCORE: 61.6

COIL: 0.6734

CONS_SCORE: 0.5127

DSS_SCORE: 0.3836

HELIX: 0.3238

FCONS_SCORE: 1.067

RIG_SCORE: 0.6587

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A564S	TCGA-DD-AACE	LIHC	TCGA	AASST	DEG_SPOP_SBC_1	0.7588
p.A564S	DO52200	LIHC	ICGC	AASST	DEG_SPOP_SBC_1	0.7588
p.A570T	DO218547	GACA	ICGC	AASST	DEG_SPOP_SBC_1	0.2778
p.A570T	DO233624	GACA	ICGC	AASST	DEG_SPOP_SBC_1	0.2778
p.L560I	TCGA-IB-7651	PAAD	TCGA	AASST	DEG_SPOP_SBC_1	0.2222
p.L560I	DO46657	PAAD	ICGC	AASST	DEG_SPOP_SBC_1	0.2222
p.S558I	DO222762	COCA	ICGC	AASST	DEG_SPOP_SBC_1	0.1667
p.G557C	TCGA-AA-3510	COAD	TCGA	AASST	DEG_SPOP_SBC_1	0.1389
p.G557C	DO7783	COAD	ICGC	AASST	DEG_SPOP_SBC_1	0.1389
p.R576W	TCGA-DA-A960	SKCM	TCGA	AASST	DEG_SPOP_SBC_1	0.1111
p.R576W	DO219482	SKCM	ICGC	AASST	DEG_SPOP_SBC_1	0.1111
p.R576W	SIDM01106	Melanoma	GDSC	AASST	DEG_SPOP_SBC_1	0.1111
p.P556L	TCGA-ER-A19G	SKCM	TCGA	AASST	DEG_SPOP_SBC_1	0.1111
p.P556L	DO47284	SKCM	ICGC	AASST	DEG_SPOP_SBC_1	0.1111
p.P556S	DO224897	BRCA	ICGC	AASST	DEG_SPOP_SBC_1	0.1111
p.A577S	ACH-002021	Endometrial/Uterine Cancer	CCLE	AASST	DEG_SPOP_SBC_1	0.0833
p.R578Q	TCGA-D7-A747	STAD	TCGA	AASST	DEG_SPOP_SBC_1	0.0556
p.R578Q	DO51735	STAD	ICGC	AASST	DEG_SPOP_SBC_1	0.0556
p.R578W	DO233693	GACA	ICGC	AASST	DEG_SPOP_SBC_1	0.0556
p.R578W	ACH-000109	Lung Cancer	CCLE	AASST	DEG_SPOP_SBC_1	0.0556

Showing 1 to 20 of 20 entries

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Drug responses associated with SIGLEC1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of AASST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2G4	Ankyrin repeat domain-containing protein 6	DEG_SPOP_SBC_1	637:641	AASST	SPOP	0.7804	More...
Q96P47	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	320:324	AASST	SPOP	0.9988	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	11:15	AASST	SPOP	0.92	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	525:529	AASST	SPOP	0.9018	More...
Q00587	Cdc42 effector protein 1	DEG_SPOP_SBC_1	277:281	AASST	SPOP	0.9931	More...
Q9HAF1	Chromatin modification-related protein MEAF6	DEG_SPOP_SBC_1	155:159	AASST	SPOP	0.6503	More...
Q9BTC0	Death-inducer obliterator 1	DEG_SPOP_SBC_1	1299:1303	AASST	SPOP	0.9885	More...
Q9NP87	DNA-directed DNA/RNA polymerase mu	DEG_SPOP_SBC_1	17:21	AASST	SPOP	0.983	More...
Q86TM6	E3 ubiquitin-protein ligase synoviolin	DEG_SPOP_SBC_1	553:557	AASST	SPOP	0.9772	More...
P15976	Erythroid transcription factor	DEG_SPOP_SBC_1	44:48	AASST	SPOP	0.6198	More...
Q96KP1	Exocyst complex component 2	DEG_SPOP_SBC_1	916:920	AASST	SPOP	0.9073	More...
Q07687	Homeobox protein DLX-2	DEG_SPOP_SBC_1	18:22	AASST	SPOP	0.9974	More...
Q9BYI3	Hyccin	DEG_SPOP_SBC_1	355:359	AASST	SPOP	0.9992	More...
Q8IU81	Interferon regulatory factor 2-binding protein 1	DEG_SPOP_SBC_1	455:459	AASST	SPOP	0.8522	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	1509:1513	AASST	SPOP	0.6304	More...
Q02078	Myocyte-specific enhancer factor 2A	DEG_SPOP_SBC_1	169:173	AASST	SPOP	0.6185	More...
P29966	Myristoylated alanine-rich C-kinase substrate	DEG_SPOP_SBC_1	129:133	AASST	SPOP	0.9228	More...
P12036	Neurofilament heavy polypeptide	DEG_SPOP_SBC_1	70:74	AASST	SPOP	0.9827	More...
Q9Y4A8	Nuclear factor erythroid 2-related factor 3	DEG_SPOP_SBC_1	132:136	AASST	SPOP	0.7076	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1554:1558	AASST	SPOP	0.9763	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1774:1778	AASST	SPOP	0.9839	More...
Q13516	Oligodendrocyte transcription factor 2	DEG_SPOP_SBC_1	90:94	AASST	SPOP	0.9738	More...
Q9Y2W3	Proton-associated sugar transporter A	DEG_SPOP_SBC_1	38:42	AASST	SPOP	0.9955	More...
Q9BZZ2	Sialoadhesin	DEG_SPOP_SBC_1	564:568	AASST	SPOP	0.8123	More...
Q15554	Telomeric repeat-binding factor 2	DEG_SPOP_SBC_1	291:295	AASST	SPOP	0.9947	More...

Showing 1 to 25 of 33 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AASST

Degron related mutations and impact score

Drug responses associated with SIGLEC1 mutations

All proteins holding degron of AASST