DegronMD - Q9BYI3(FAM126A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G350E	TCGA-06-5416	GBM	TCGA	AASST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1944
p.G350E	DO225098	BRCA	ICGC	AASST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1944
p.G350E	DO10880	GBM	ICGC	AASST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1944
p.E296K	TCGA-38-4631	LUAD	TCGA	VEITPTSS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.1389
p.E296K	DO24970	LUAD	ICGC	VEITPTSS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.1389
p.R314I	TCGA-A5-A2K5	UCEC	TCGA	VEITPTSS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.2222
p.R314I	DO41379	UCEC	ICGC	VEITPTSS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.2222
p.R311Q	TCGA-CA-6718	COAD	TCGA	VEITPTSS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.3056
p.R311Q	TCGA-EO-A3B0	UCEC	TCGA	VEITPTSS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.3056
p.R311Q	DO7801	COAD	ICGC	VEITPTSS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.3056
p.R311Q	DO219773	UCEC	ICGC	VEITPTSS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.3056
p.R299M	TCGA-CM-6171	COAD	TCGA	VEITPTSS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.2222
p.R299M	DO8151	COAD	ICGC	VEITPTSS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.2222
p.C300R	TCGA-DI-A1BU	UCEC	TCGA	VEITPTSS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.25
p.C300R	DO42023	UCEC	ICGC	VEITPTSS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.25
p.C300Y	TCGA-MP-A4TE	LUAD	TCGA	VEITPTSS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.25
p.C300Y	DO45410	LUAD	ICGC	VEITPTSS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.25
p.E349K	DO225233	BRCA	ICGC	AASST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1667
p.E349K	ACH-000237	Ovarian Cancer	CCLE	AASST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1667
p.G357R	DO222834	BTCA	ICGC	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.7568
p.G357R	DO228611	GACA	ICGC	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.7568
p.G361R	DO222774	COCA	ICGC	AASST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.2778
p.K365R	DO222822	COCA	ICGC	AASST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1667
p.T308P	DO234412	ESAD	ICGC	VEITPTSS	DEG_SCF_FBW7_1	303:310	Mutation altering degron motif	0.5919
p.E349G	DO233205	GACA	ICGC	AASST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1667
p.R311P	DO233876	GACA	ICGC	VEITPTSS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.3056
p.A355T	DO228359	LICA	ICGC	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.7139
p.A355D	DO228976	LICA	ICGC	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.7793
p.T353K	DO229035	LICA	ICGC	AASST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.2778
p.T368K	DO229037	LICA	ICGC	AASST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.0833
p.T368I	DO221547	PACA	ICGC	AASST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.0833
p.R359I	DO41020	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.8102
p.F351L	DO229542	UTCA	ICGC	AASST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.2222
p.S345T	SIDM00845	Burkitt's Lymphoma	GDSC	AASST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.0556
p.S345T	Daudi	haematopoietic and lymphoid tissue	COSMIC	AASST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.0556
p.A356S	SIDM00845	Burkitt's Lymphoma	GDSC	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.6477
p.N354H	SIDM00845	Burkitt's Lymphoma	GDSC	AASST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.3056
p.A356V	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.5825
p.A356V	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.5825
p.A356V	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.5825
p.A356V	SIDM00274	Gastric Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.5825
p.A356V	SIDM01551	Gastric Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.5825
p.A356V	ACH-000047	Gastric Cancer	CCLE	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.5825
p.A356V	ACH-000485	Gastric Cancer	CCLE	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.5825
p.A356V	ACH-000843	Lung Cancer	CCLE	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.5825
p.A356V	ACH-002264	Esophageal Cancer	CCLE	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.5825
p.A356V	PC-3_[JPC-3]	lung	COSMIC	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.5825
p.A356V	KYSE-50	oesophagus	COSMIC	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.5825
p.A356V	HARA	lung	COSMIC	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.5825
p.A356V	GCIY	stomach	COSMIC	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.5825
p.T360I	SIDM01194	Hepatocellular Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	355:359	Mutation blocking phosphorylation signal	0.75
p.A355V	SIDM00808	Burkitt's Lymphoma	GDSC	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.5825
p.A355V	SIDM01254	Burkitt's Lymphoma	GDSC	AASST	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.5825
p.A316G	ACH-001030	Bone Cancer	CCLE	VEITPTSS	DEG_SCF_FBW7_1	303:310	Mutation rewiring degron network	0.1667
p.N366K	ACH-002461	Skin Cancer	CCLE	AASST	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM126A

UniProt ID: Q9BYI3

Entrez ID: 84668

Protein name: Hyccin (Down-regulated by CTNNB1 protein A) (Protein FAM126A)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for FAM126A in