DegronMD

Uniprot ID: Q9BYI3

Source protein: Hyccin

Source gene: FAM126A

Class: DEG_SCF_FBW7_1

Location: 303:310

E3 ligase: FBXW7

DEGRON score: 0.9994

ASA_SCORE: 81.2

COIL: 0.7836

CONS_SCORE: 0.4366

DSS_SCORE: 0.4863

HELIX: 0.02

FCONS_SCORE: 0.7927

RIG_SCORE: 0.775

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E296K	TCGA-38-4631	LUAD	TCGA	VEITPTSS	DEG_SCF_FBW7_1	0.1389
p.E296K	DO24970	LUAD	ICGC	VEITPTSS	DEG_SCF_FBW7_1	0.1389
p.R314I	TCGA-A5-A2K5	UCEC	TCGA	VEITPTSS	DEG_SCF_FBW7_1	0.2222
p.R314I	DO41379	UCEC	ICGC	VEITPTSS	DEG_SCF_FBW7_1	0.2222
p.R311Q	TCGA-CA-6718	COAD	TCGA	VEITPTSS	DEG_SCF_FBW7_1	0.3056
p.R311Q	TCGA-EO-A3B0	UCEC	TCGA	VEITPTSS	DEG_SCF_FBW7_1	0.3056
p.R311Q	DO7801	COAD	ICGC	VEITPTSS	DEG_SCF_FBW7_1	0.3056
p.R311Q	DO219773	UCEC	ICGC	VEITPTSS	DEG_SCF_FBW7_1	0.3056
p.R299M	TCGA-CM-6171	COAD	TCGA	VEITPTSS	DEG_SCF_FBW7_1	0.2222
p.R299M	DO8151	COAD	ICGC	VEITPTSS	DEG_SCF_FBW7_1	0.2222
p.C300R	TCGA-DI-A1BU	UCEC	TCGA	VEITPTSS	DEG_SCF_FBW7_1	0.25
p.C300R	DO42023	UCEC	ICGC	VEITPTSS	DEG_SCF_FBW7_1	0.25
p.C300Y	TCGA-MP-A4TE	LUAD	TCGA	VEITPTSS	DEG_SCF_FBW7_1	0.25
p.C300Y	DO45410	LUAD	ICGC	VEITPTSS	DEG_SCF_FBW7_1	0.25
p.T308P	DO234412	ESAD	ICGC	VEITPTSS	DEG_SCF_FBW7_1	0.5919
p.R311P	DO233876	GACA	ICGC	VEITPTSS	DEG_SCF_FBW7_1	0.3056
p.A316G	ACH-001030	Bone Cancer	CCLE	VEITPTSS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYI3	Hyccin	DEG_SCF_FBW7_1	303:310	VEITPTSS	FBXW7	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons