DegronMD

Uniprot ID: Q9BYI3

Source protein: Hyccin

Source gene: FAM126A

Class: DEG_SPOP_SBC_1

Location: 355:359

E3 ligase: SPOP

DEGRON score: 0.9992

ASA_SCORE: 76.88

COIL: 0.8162

CONS_SCORE: 0.3544

DSS_SCORE: 0.5278

HELIX: 0.1622

FCONS_SCORE: 0.9854

RIG_SCORE: 0.6428

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G350E	TCGA-06-5416	GBM	TCGA	AASST	DEG_SPOP_SBC_1	0.1944
p.G350E	DO225098	BRCA	ICGC	AASST	DEG_SPOP_SBC_1	0.1944
p.G350E	DO10880	GBM	ICGC	AASST	DEG_SPOP_SBC_1	0.1944
p.E349K	DO225233	BRCA	ICGC	AASST	DEG_SPOP_SBC_1	0.1667
p.E349K	ACH-000237	Ovarian Cancer	CCLE	AASST	DEG_SPOP_SBC_1	0.1667
p.G357R	DO222834	BTCA	ICGC	AASST	DEG_SPOP_SBC_1	0.7568
p.G357R	DO228611	GACA	ICGC	AASST	DEG_SPOP_SBC_1	0.7568
p.G361R	DO222774	COCA	ICGC	AASST	DEG_SPOP_SBC_1	0.2778
p.K365R	DO222822	COCA	ICGC	AASST	DEG_SPOP_SBC_1	0.1667
p.E349G	DO233205	GACA	ICGC	AASST	DEG_SPOP_SBC_1	0.1667
p.A355T	DO228359	LICA	ICGC	AASST	DEG_SPOP_SBC_1	0.7139
p.A355D	DO228976	LICA	ICGC	AASST	DEG_SPOP_SBC_1	0.7793
p.T353K	DO229035	LICA	ICGC	AASST	DEG_SPOP_SBC_1	0.2778
p.T368K	DO229037	LICA	ICGC	AASST	DEG_SPOP_SBC_1	0.0833
p.T368I	DO221547	PACA	ICGC	AASST	DEG_SPOP_SBC_1	0.0833
p.R359I	DO41020	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	0.8102
p.F351L	DO229542	UTCA	ICGC	AASST	DEG_SPOP_SBC_1	0.2222
p.S345T	SIDM00845	Burkitt's Lymphoma	GDSC	AASST	DEG_SPOP_SBC_1	0.0556
p.S345T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AASST	DEG_SPOP_SBC_1	0.0556
p.A356S	SIDM00845	Burkitt's Lymphoma	GDSC	AASST	DEG_SPOP_SBC_1	0.6477
p.N354H	SIDM00845	Burkitt's Lymphoma	GDSC	AASST	DEG_SPOP_SBC_1	0.3056
p.A356V	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	0.5825
p.A356V	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	0.5825
p.A356V	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	0.5825
p.A356V	SIDM00274	Gastric Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	0.5825
p.A356V	SIDM01551	Gastric Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	0.5825
p.A356V	ACH-000047	Gastric Cancer	CCLE	AASST	DEG_SPOP_SBC_1	0.5825
p.A356V	ACH-000485	Gastric Cancer	CCLE	AASST	DEG_SPOP_SBC_1	0.5825
p.A356V	ACH-000843	Lung Cancer	CCLE	AASST	DEG_SPOP_SBC_1	0.5825
p.A356V	ACH-002264	Esophageal Cancer	CCLE	AASST	DEG_SPOP_SBC_1	0.5825
p.A356V	PC-3_[JPC-3]	lung	COSMIC	AASST	DEG_SPOP_SBC_1	0.5825
p.A356V	KYSE-50	oesophagus	COSMIC	AASST	DEG_SPOP_SBC_1	0.5825
p.A356V	HARA	lung	COSMIC	AASST	DEG_SPOP_SBC_1	0.5825
p.A356V	GCIY	stomach	COSMIC	AASST	DEG_SPOP_SBC_1	0.5825
p.T360I	SIDM01194	Hepatocellular Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	0.75
p.A355V	SIDM00808	Burkitt's Lymphoma	GDSC	AASST	DEG_SPOP_SBC_1	0.5825
p.A355V	SIDM01254	Burkitt's Lymphoma	GDSC	AASST	DEG_SPOP_SBC_1	0.5825
p.N366K	ACH-002461	Skin Cancer	CCLE	AASST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2VDJ0	Transmembrane protein 131-like	DEG_SPOP_SBC_1	993:997	AASST	SPOP	0.9931	More...
P12036	Neurofilament heavy polypeptide	DEG_SPOP_SBC_1	70:74	AASST	SPOP	0.9827	More...
P15976	Erythroid transcription factor	DEG_SPOP_SBC_1	44:48	AASST	SPOP	0.6198	More...
P29966	Myristoylated alanine-rich C-kinase substrate	DEG_SPOP_SBC_1	129:133	AASST	SPOP	0.9228	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1554:1558	AASST	SPOP	0.9763	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1774:1778	AASST	SPOP	0.9839	More...
Q00587	Cdc42 effector protein 1	DEG_SPOP_SBC_1	277:281	AASST	SPOP	0.9931	More...
Q02078	Myocyte-specific enhancer factor 2A	DEG_SPOP_SBC_1	169:173	AASST	SPOP	0.6185	More...
Q07687	Homeobox protein DLX-2	DEG_SPOP_SBC_1	18:22	AASST	SPOP	0.9974	More...
Q13516	Oligodendrocyte transcription factor 2	DEG_SPOP_SBC_1	90:94	AASST	SPOP	0.9738	More...
Q15554	Telomeric repeat-binding factor 2	DEG_SPOP_SBC_1	291:295	AASST	SPOP	0.9947	More...
Q15714	TSC22 domain family protein 1	DEG_SPOP_SBC_1	70:74	AASST	SPOP	0.9918	More...
Q15814	Tubulin-specific chaperone C	DEG_SPOP_SBC_1	146:150	AASST	SPOP	0.5577	More...
Q86TM6	E3 ubiquitin-protein ligase synoviolin	DEG_SPOP_SBC_1	553:557	AASST	SPOP	0.9772	More...
Q8IU81	Interferon regulatory factor 2-binding protein 1	DEG_SPOP_SBC_1	455:459	AASST	SPOP	0.8522	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	1097:1101	AASST	SPOP	0.9707	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	136:140	AASST	SPOP	0.9889	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	156:160	AASST	SPOP	0.9963	More...
Q96KP1	Exocyst complex component 2	DEG_SPOP_SBC_1	916:920	AASST	SPOP	0.9073	More...
Q96P47	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	320:324	AASST	SPOP	0.9988	More...
Q9BTC0	Death-inducer obliterator 1	DEG_SPOP_SBC_1	1299:1303	AASST	SPOP	0.9885	More...
Q9BXT5	Testis-expressed protein 15	DEG_SPOP_SBC_1	1366:1370	AASST	SPOP	0.5082	More...
Q9BYI3	Hyccin	DEG_SPOP_SBC_1	355:359	AASST	SPOP	0.9992	More...
Q9BZZ2	Sialoadhesin	DEG_SPOP_SBC_1	564:568	AASST	SPOP	0.8123	More...
Q9C0A1	Zinc finger homeobox protein 2	DEG_SPOP_SBC_1	43:47	AASST	SPOP	0.9864	More...
Q9HAF1	Chromatin modification-related protein MEAF6	DEG_SPOP_SBC_1	155:159	AASST	SPOP	0.6503	More...
Q9NP87	DNA-directed DNA/RNA polymerase mu	DEG_SPOP_SBC_1	17:21	AASST	SPOP	0.983	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	1509:1513	AASST	SPOP	0.6304	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	11:15	AASST	SPOP	0.92	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	525:529	AASST	SPOP	0.9018	More...
Q9Y4A8	Nuclear factor erythroid 2-related factor 3	DEG_SPOP_SBC_1	132:136	AASST	SPOP	0.7076	More...
Q9Y2G4	Ankyrin repeat domain-containing protein 6	DEG_SPOP_SBC_1	637:641	AASST	SPOP	0.7804	More...
Q9Y2W3	Proton-associated sugar transporter A	DEG_SPOP_SBC_1	38:42	AASST	SPOP	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AASST

Degron related mutations and impact score

Drug responses associated with FAM126A mutations

All proteins holding degron of AASST