DegronMD - Q15554(TERF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K242T	TCGA-5M-AAT6	COAD	TCGA	LRNDLLNII	DEG_APCC_DBOX_1	233:241	Mutation rewiring degron network	0.3056
p.K242T	DO223703	COAD	ICGC	LRNDLLNII	DEG_APCC_DBOX_1	233:241	Mutation rewiring degron network	0.3056
p.E233K	TCGA-A5-A0G2	UCEC	TCGA	LRNDLLNII	DEG_APCC_DBOX_1	233:241	Mutation altering degron motif	0.7022
p.E233K	DO41235	UCEC	ICGC	LRNDLLNII	DEG_APCC_DBOX_1	233:241	Mutation altering degron motif	0.7022
p.R223H	TCGA-AX-A06F	UCEC	TCGA	LRNDLLNII	DEG_APCC_DBOX_1	233:241	Mutation rewiring degron network	0.0556
p.R223H	DO41752	UCEC	ICGC	LRNDLLNII	DEG_APCC_DBOX_1	233:241	Mutation rewiring degron network	0.0556
p.D231G	TCGA-CG-4442	STAD	TCGA	LRNDLLNII	DEG_APCC_DBOX_1	233:241	Mutation rewiring degron network	0.2778
p.D231G	DO38380	STAD	ICGC	LRNDLLNII	DEG_APCC_DBOX_1	233:241	Mutation rewiring degron network	0.2778
p.D231G	DO229245	THCA	ICGC	LRNDLLNII	DEG_APCC_DBOX_1	233:241	Mutation rewiring degron network	0.2778
p.K293N	TCGA-E2-A1LH	BRCA	TCGA	AASST	DEG_SPOP_SBC_1	291:295	Mutation altering degron motif	0.6918
p.T287I	TCGA-EO-A3B0	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	291:295	Mutation substituting flanking lysine	0.3333
p.T287I	DO219773	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	291:295	Mutation substituting flanking lysine	0.3333
p.T281I	TCGA-G5-6641	READ	TCGA	AASST	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.0556
p.T281I	DO36909	READ	ICGC	AASST	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.0556
p.H228Q	TCGA-IQ-A61I	HNSC	TCGA	LRNDLLNII	DEG_APCC_DBOX_1	233:241	Mutation rewiring degron network	0.1944
p.H228Q	DO49032	HNSC	ICGC	LRNDLLNII	DEG_APCC_DBOX_1	233:241	Mutation rewiring degron network	0.1944
p.R282C	DO8400	COAD	ICGC	AASST	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.0833
p.K289I	DO234276	ESAD	ICGC	AASST	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.2778
p.A303E	DO229037	LICA	ICGC	AASST	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.1111
p.S286F	DO38511	STAD	ICGC	AASST	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.1944
p.P287S	DO38511	STAD	ICGC	AASST	DEG_SPOP_SBC_1	291:295	Mutation substituting flanking lysine	0.3333
p.G296E	SIDM00572	Gastric Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.3056
p.G296E	ACH-000911	Gastric Cancer	CCLE	AASST	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.3056
p.G296E	NUGC-3	stomach	COSMIC	AASST	DEG_SPOP_SBC_1	291:295	Mutation rewiring degron network	0.3056
p.A291T	SIDM00364	B-Lymphoblastic Leukemia	GDSC	AASST	DEG_SPOP_SBC_1	291:295	Mutation altering degron motif	0.7139
p.A291T	ACH-002059	Leukemia	CCLE	AASST	DEG_SPOP_SBC_1	291:295	Mutation altering degron motif	0.7139
p.A291T	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	AASST	DEG_SPOP_SBC_1	291:295	Mutation altering degron motif	0.7139
p.I240S	SIDM00282	Colorectal Carcinoma	GDSC	LRNDLLNII	DEG_APCC_DBOX_1	233:241	Mutation altering degron motif	0.7341
p.I240S	ACH-000998	Colon/Colorectal Cancer	CCLE	LRNDLLNII	DEG_APCC_DBOX_1	233:241	Mutation altering degron motif	0.7341
p.I240S	CW-2	large intestine	COSMIC	LRNDLLNII	DEG_APCC_DBOX_1	233:241	Mutation altering degron motif	0.7341
p.G284D	MFE-319	endometrium	COSMIC	AASST	DEG_SPOP_SBC_1	291:295	Mutation substituting flanking lysine	0.25

Kaplan plot for TERF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TERF2

UniProt ID: Q15554

Entrez ID: 7014

Protein name: Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TERF2 in