DegronMD

Uniprot ID: Q15554

Source protein: Telomeric repeat-binding factor 2

Source gene: TERF2

Class: DEG_APCC_DBOX_1

Location: 233:241

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8851

ASA_SCORE: 53.7222

COIL: 0.0218

CONS_SCORE: 0.5718

DSS_SCORE: 0.3457

HELIX: 0.9751

FCONS_SCORE: 1.2774

RIG_SCORE: 0.8387

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K242T	TCGA-5M-AAT6	COAD	TCGA	LRNDLLNII	DEG_APCC_DBOX_1	0.3056
p.K242T	DO223703	COAD	ICGC	LRNDLLNII	DEG_APCC_DBOX_1	0.3056
p.E233K	TCGA-A5-A0G2	UCEC	TCGA	LRNDLLNII	DEG_APCC_DBOX_1	0.7022
p.E233K	DO41235	UCEC	ICGC	LRNDLLNII	DEG_APCC_DBOX_1	0.7022
p.R223H	TCGA-AX-A06F	UCEC	TCGA	LRNDLLNII	DEG_APCC_DBOX_1	0.0556
p.R223H	DO41752	UCEC	ICGC	LRNDLLNII	DEG_APCC_DBOX_1	0.0556
p.D231G	TCGA-CG-4442	STAD	TCGA	LRNDLLNII	DEG_APCC_DBOX_1	0.2778
p.D231G	DO38380	STAD	ICGC	LRNDLLNII	DEG_APCC_DBOX_1	0.2778
p.D231G	DO229245	THCA	ICGC	LRNDLLNII	DEG_APCC_DBOX_1	0.2778
p.H228Q	TCGA-IQ-A61I	HNSC	TCGA	LRNDLLNII	DEG_APCC_DBOX_1	0.1944
p.H228Q	DO49032	HNSC	ICGC	LRNDLLNII	DEG_APCC_DBOX_1	0.1944
p.I240S	SIDM00282	Colorectal Carcinoma	GDSC	LRNDLLNII	DEG_APCC_DBOX_1	0.7341
p.I240S	ACH-000998	Colon/Colorectal Cancer	CCLE	LRNDLLNII	DEG_APCC_DBOX_1	0.7341
p.I240S	CW-2	large_intestine	COSMIC	LRNDLLNII	DEG_APCC_DBOX_1	0.7341

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15554	Telomeric repeat-binding factor 2	DEG_APCC_DBOX_1	233:241	LRNDLLNII	APC,CDC20,FZR1	0.8851	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons