DegronMD - Q13516(OLIG2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P49L	TCGA-AP-A1E1	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.P49L	DO43226	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.A53V	TCGA-B5-A0JY	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0556
p.A53V	DO43041	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0556
p.A53V	ACH-000997	Colon/Colorectal Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0556
p.A53V	ACH-001061	Colon/Colorectal Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0556
p.A53V	ACH-001091	Colon/Colorectal Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0556
p.T94I	TCGA-B5-A1MX	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	90:94	Mutation altering degron motif	0.7078
p.T94I	TCGA-DI-A1BU	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	90:94	Mutation altering degron motif	0.7078
p.T94I	DO42023	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	90:94	Mutation altering degron motif	0.7078
p.T94I	DO41999	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	90:94	Mutation altering degron motif	0.7078
p.A53T	TCGA-BR-8368	STAD	TCGA	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0556
p.A53T	DO47981	STAD	ICGC	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0556
p.A53T	ACH-000722	Colon/Colorectal Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0556
p.S88A	TCGA-D6-6515	HNSC	TCGA	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	TCGA-GU-A762	BLCA	TCGA	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	TCGA-HU-A4G8	STAD	TCGA	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	TCGA-VQ-A923	STAD	TCGA	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	DO51887	BLCA	ICGC	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	DO50401	ESAD	ICGC	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	DO234349	ESAD	ICGC	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	DO233646	GACA	ICGC	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	DO233665	GACA	ICGC	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	DO233944	GACA	ICGC	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	DO14206	HNSC	ICGC	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	DO50731	ORCA	ICGC	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	DO47819	STAD	ICGC	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	DO222361	STAD	ICGC	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	SIDM01267	Non-Cancerous	GDSC	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	SIDM01090	Colorectal Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	SIDM00568	Gastric Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	ACH-000247	Gastric Cancer	CCLE	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	ACH-000943	Colon/Colorectal Cancer	CCLE	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	RKO	large intestine	COSMIC	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.S88A	OCUM-1	stomach	COSMIC	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.2778
p.A33T	TCGA-FD-A5C0	BLCA	TCGA	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.A33T	DO44046	BLCA	ICGC	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.A33T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.A33T	ACH-001518	Endometrial/Uterine Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.A33T	ACH-002256	Leukemia	CCLE	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.A33T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.S85C	TCGA-IR-A3LK	CESC	TCGA	AASST	DEG_SPOP_SBC_1	90:94	Mutation blocking phosphorylation signal	0.6389
p.S85C	DO44299	CESC	ICGC	AASST	DEG_SPOP_SBC_1	90:94	Mutation blocking phosphorylation signal	0.6389
p.P48R	TCGA-NC-A5HI	LUSC	TCGA	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1944
p.P48R	DO45461	LUSC	ICGC	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1944
p.D97N	TCGA-OR-A5LL	ACC	TCGA	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.25
p.P48L	DO50441	ESAD	ICGC	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1944
p.A89S	DO234353	ESAD	ICGC	AASST	DEG_SPOP_SBC_1	90:94	Mutation rewiring degron network	0.3056
p.G37V	DO228978	LICA	ICGC	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.2778
p.C47F	DO229015	LICA	ICGC	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.2222
p.C47F	DO229026	LICA	ICGC	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.2222
p.S41L	SIDM00777	Colorectal Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	39:43	Mutation altering degron motif	0.7667
p.S41L	ACH-000360	Colon/Colorectal Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	39:43	Mutation altering degron motif	0.7667
p.S41L	NCI-H508	large intestine	COSMIC	VSSST	DEG_SPOP_SBC_1	39:43	Mutation altering degron motif	0.7667
p.S52R	SIDM00633	Breast Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0833
p.S52R	ACH-000759	Breast Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0833
p.S52R	MDA-MB-175-VII	breast	COSMIC	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0833
p.K98N	SIDM00170	Head and Neck Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	90:94	Mutation substituting flanking lysine	0.3333
p.K98N	ACH-000682	Head and Neck Cancer	CCLE	AASST	DEG_SPOP_SBC_1	90:94	Mutation substituting flanking lysine	0.3333
p.G36V	ACH-001145	Ovarian Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.25

Kaplan plot for OLIG2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OLIG2

UniProt ID: Q13516

Entrez ID: 10215

Protein name: Oligodendrocyte transcription factor 2 (Oligo2) (Class B basic helix-loop-helix protein 1) (bHLHb1) (Class E basic helix-loop-helix protein 19) (bHLHe19) (Protein kinase C-binding protein 2) (Protein kinase C-binding protein RACK17)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OLIG2 in