DegronMD

Uniprot ID: Q13516

Source protein: Oligodendrocyte transcription factor 2

Source gene: OLIG2

Class: DEG_SPOP_SBC_1

Location: 39:43

E3 ligase: SPOP

DEGRON score: 0.9992

ASA_SCORE: 79.98

COIL: 0.9564

CONS_SCORE: 0.4972

DSS_SCORE: 0.6202

HELIX: 0.0146

FCONS_SCORE: 1.0981

RIG_SCORE: 0.5945

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P49L	TCGA-AP-A1E1	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	0.1667
p.P49L	DO43226	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	0.1667
p.A53V	TCGA-B5-A0JY	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	0.0556
p.A53V	DO43041	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	0.0556
p.A53V	ACH-000997	Colon/Colorectal Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	0.0556
p.A53V	ACH-001061	Colon/Colorectal Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	0.0556
p.A53V	ACH-001091	Colon/Colorectal Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	0.0556
p.A53T	TCGA-BR-8368	STAD	TCGA	VSSST	DEG_SPOP_SBC_1	0.0556
p.A53T	DO47981	STAD	ICGC	VSSST	DEG_SPOP_SBC_1	0.0556
p.A53T	ACH-000722	Colon/Colorectal Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	0.0556
p.A33T	TCGA-FD-A5C0	BLCA	TCGA	VSSST	DEG_SPOP_SBC_1	0.1667
p.A33T	DO44046	BLCA	ICGC	VSSST	DEG_SPOP_SBC_1	0.1667
p.A33T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VSSST	DEG_SPOP_SBC_1	0.1667
p.A33T	ACH-001518	Endometrial/Uterine Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	0.1667
p.A33T	ACH-002256	Leukemia	CCLE	VSSST	DEG_SPOP_SBC_1	0.1667
p.A33T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	0.1667
p.P48R	TCGA-NC-A5HI	LUSC	TCGA	VSSST	DEG_SPOP_SBC_1	0.1944
p.P48R	DO45461	LUSC	ICGC	VSSST	DEG_SPOP_SBC_1	0.1944
p.P48L	DO50441	ESAD	ICGC	VSSST	DEG_SPOP_SBC_1	0.1944
p.G37V	DO228978	LICA	ICGC	VSSST	DEG_SPOP_SBC_1	0.2778
p.C47F	DO229015	LICA	ICGC	VSSST	DEG_SPOP_SBC_1	0.2222
p.C47F	DO229026	LICA	ICGC	VSSST	DEG_SPOP_SBC_1	0.2222
p.S41L	SIDM00777	Colorectal Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.7667
p.S41L	ACH-000360	Colon/Colorectal Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	0.7667
p.S41L	NCI-H508	large_intestine	COSMIC	VSSST	DEG_SPOP_SBC_1	0.7667
p.S52R	SIDM00633	Breast Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.0833
p.S52R	ACH-000759	Breast Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	0.0833
p.S52R	MDA-MB-175-VII	breast	COSMIC	VSSST	DEG_SPOP_SBC_1	0.0833
p.G36V	ACH-001145	Ovarian Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60237	Protein phosphatase 1 regulatory subunit 12B	DEG_SPOP_SBC_1	574:578	VSSST	SPOP	0.9726	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2573:2577	VSSST	SPOP	0.768	More...
O75496	Geminin	DEG_SPOP_SBC_1	199:203	VSSST	SPOP	0.9991	More...
O95935	T-box transcription factor TBX18	DEG_SPOP_SBC_1	460:464	VSSST	SPOP	0.9891	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1797:1801	VSSST	SPOP	0.9347	More...
Q12951	Forkhead box protein I1	DEG_SPOP_SBC_1	222:226	VSSST	SPOP	0.9895	More...
Q13433	Zinc transporter ZIP6	DEG_SPOP_SBC_1	218:222	VSSST	SPOP	0.9963	More...
Q13516	Oligodendrocyte transcription factor 2	DEG_SPOP_SBC_1	39:43	VSSST	SPOP	0.9992	More...
Q2LD37	Transmembrane protein KIAA1109	DEG_SPOP_SBC_1	4029:4033	VSSST	SPOP	0.5866	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	5734:5738	VSSST	SPOP	0.9977	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2933:2937	VSSST	SPOP	0.996	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	1005:1009	VSSST	SPOP	0.9988	More...
Q8NEZ2	Vacuolar protein sorting-associated protein 37A	DEG_SPOP_SBC_1	179:183	VSSST	SPOP	0.9741	More...
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	835:839	VSSST	SPOP	0.9941	More...
Q96IZ0	PRKC apoptosis WT1 regulator protein	DEG_SPOP_SBC_1	263:267	VSSST	SPOP	0.7604	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	155:159	VSSST	SPOP	0.9548	More...
Q9UJT9	F-box/LRR-repeat protein 7	DEG_SPOP_SBC_1	23:27	VSSST	SPOP	0.9977	More...
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_SPOP_SBC_1	659:663	VSSST	SPOP	0.9709	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	365:369	VSSST	SPOP	0.9057	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSSST

Degron related mutations and impact score

Drug responses associated with OLIG2 mutations

All proteins holding degron of VSSST