DegronMD - O75496(GMNN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W99C	TCGA-13-2060	OV	TCGA	IKENP	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1944
p.W99C	DO30170	OV	ICGC	IKENP	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1944
p.S202F	TCGA-21-1070	LUSC	TCGA	VSSST	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.9093
p.S202F	DO27088	LUSC	ICGC	VSSST	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.9093
p.E104Q	TCGA-4Z-AA7R	BLCA	TCGA	IKENP	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.0556
p.E104Q	TCGA-B5-A0K4	UCEC	TCGA	IKENP	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.0556
p.E104Q	DO51866	BLCA	ICGC	IKENP	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.0556
p.E104Q	DO42360	UCEC	ICGC	IKENP	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.0556
p.E190D	TCGA-A5-A0G2	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0833
p.E190D	DO41235	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0833
p.T193M	TCGA-A5-A0G2	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1667
p.T193M	DO41235	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1667
p.S20Y	TCGA-AP-A1DV	UCEC	TCGA	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2778
p.S20Y	DO43186	UCEC	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2778
p.P22L	TCGA-D3-A8GI	SKCM	TCGA	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.6471
p.P22L	DO50284	SKCM	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.6471
p.N93I	TCGA-DU-6392	LGG	TCGA	IKENP	DEG_APCC_KENBOX_2	90:94	Mutation altering degron motif	0.728
p.N93I	DO22237	LGG	ICGC	IKENP	DEG_APCC_KENBOX_2	90:94	Mutation altering degron motif	0.728
p.E14D	TCGA-FU-A3HZ	CESC	TCGA	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.1111
p.E14D	DO6308	CESC	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.1111
p.S34F	TCGA-W3-A824	SKCM	TCGA	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation blocking phosphorylation signal	0.6667
p.S34F	DO51271	SKCM	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation blocking phosphorylation signal	0.6667
p.N18T	DO222809	COCA	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2222
p.N18T	DO229010	COCA	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2222
p.N18T	DO229013	COCA	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2222
p.N18T	DO229016	COCA	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2222
p.N18T	DO229003	COCA	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2222
p.N18T	DO229005	COCA	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2222
p.N18T	DO223145	ESCA	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2222
p.N18T	DO52365	LUSC	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2222
p.C194G	DO233780	GACA	ICGC	VSSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1944
p.A195T	DO228938	LICA	ICGC	VSSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.2222
p.V102L	DO229024	LICA	ICGC	IKENP	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1111
p.V102L	DO229027	LICA	ICGC	IKENP	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1111
p.G197V	DO229035	LICA	ICGC	VSSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.2778
p.F86L	DO52669	MALY	ICGC	IKENP	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.2222
p.P207L	DO220899	MELA	ICGC	VSSST	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.2222
p.S20P	SIDM00537	Colorectal Carcinoma	GDSC	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2778
p.S20P	ACH-000982	Colon/Colorectal Cancer	CCLE	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2778
p.S20P	ACH-001345	Colon/Colorectal Cancer	CCLE	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2778
p.S20P	GP5d	large intestine	COSMIC	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2778
p.V199A	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VSSST	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.5825
p.V199A	SIDM00153	T-Lymphoblastic Leukemia	GDSC	VSSST	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.5825
p.V199A	ACH-000964	Leukemia	CCLE	VSSST	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.5825
p.V199A	ACH-001127	Leukemia	CCLE	VSSST	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.5825
p.V199A	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.5825
p.R23K	ACH-002044	Head and Neck Cancer	CCLE	PRRTLKMIQ	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.7237

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GMNN

UniProt ID: O75496

Entrez ID: 51053

Protein name: Geminin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GMNN in