DegronMD

Uniprot ID: O75496

Source protein: Geminin

Source gene: GMNN

Class: DEG_APCC_DBOX_1

Location: 22:30

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9643

ASA_SCORE: 71.4556

COIL: 0.6549

CONS_SCORE: 0.7507

DSS_SCORE: 0.6126

HELIX: 0.0518

FCONS_SCORE: 1.1504

RIG_SCORE: 0.7376

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S20Y	TCGA-AP-A1DV	UCEC	TCGA	PRRTLKMIQ	DEG_APCC_DBOX_1	0.2778
p.S20Y	DO43186	UCEC	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	0.2778
p.P22L	TCGA-D3-A8GI	SKCM	TCGA	PRRTLKMIQ	DEG_APCC_DBOX_1	0.6471
p.P22L	DO50284	SKCM	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	0.6471
p.E14D	TCGA-FU-A3HZ	CESC	TCGA	PRRTLKMIQ	DEG_APCC_DBOX_1	0.1111
p.E14D	DO6308	CESC	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	0.1111
p.S34F	TCGA-W3-A824	SKCM	TCGA	PRRTLKMIQ	DEG_APCC_DBOX_1	0.6667
p.S34F	DO51271	SKCM	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	0.6667
p.N18T	DO222809	COCA	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	0.2222
p.N18T	DO229010	COCA	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	0.2222
p.N18T	DO229013	COCA	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	0.2222
p.N18T	DO229016	COCA	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	0.2222
p.N18T	DO229003	COCA	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	0.2222
p.N18T	DO229005	COCA	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	0.2222
p.N18T	DO223145	ESCA	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	0.2222
p.N18T	DO52365	LUSC	ICGC	PRRTLKMIQ	DEG_APCC_DBOX_1	0.2222
p.S20P	SIDM00537	Colorectal Carcinoma	GDSC	PRRTLKMIQ	DEG_APCC_DBOX_1	0.2778
p.S20P	ACH-000982	Colon/Colorectal Cancer	CCLE	PRRTLKMIQ	DEG_APCC_DBOX_1	0.2778
p.S20P	ACH-001345	Colon/Colorectal Cancer	CCLE	PRRTLKMIQ	DEG_APCC_DBOX_1	0.2778
p.S20P	GP5d	large_intestine	COSMIC	PRRTLKMIQ	DEG_APCC_DBOX_1	0.2778
p.R23K	ACH-002044	Head and Neck Cancer	CCLE	PRRTLKMIQ	DEG_APCC_DBOX_1	0.7237

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75496	Geminin	DEG_APCC_DBOX_1	22:30	PRRTLKMIQ	APC,CDC20,FZR1	0.9643	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons