DegronMD

Uniprot ID: O75496

Source protein: Geminin

Source gene: GMNN

Class: DEG_APCC_KENBOX_2

Location: 90:94

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9695

ASA_SCORE: 93.06

COIL: 0.8708

CONS_SCORE: 0.6733

DSS_SCORE: 0.3713

HELIX: 0.107

FCONS_SCORE: 0.881

RIG_SCORE: 0.7425

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W99C	TCGA-13-2060	OV	TCGA	IKENP	DEG_APCC_KENBOX_2	0.1944
p.W99C	DO30170	OV	ICGC	IKENP	DEG_APCC_KENBOX_2	0.1944
p.E104Q	TCGA-4Z-AA7R	BLCA	TCGA	IKENP	DEG_APCC_KENBOX_2	0.0556
p.E104Q	TCGA-B5-A0K4	UCEC	TCGA	IKENP	DEG_APCC_KENBOX_2	0.0556
p.E104Q	DO51866	BLCA	ICGC	IKENP	DEG_APCC_KENBOX_2	0.0556
p.E104Q	DO42360	UCEC	ICGC	IKENP	DEG_APCC_KENBOX_2	0.0556
p.N93I	TCGA-DU-6392	LGG	TCGA	IKENP	DEG_APCC_KENBOX_2	0.728
p.N93I	DO22237	LGG	ICGC	IKENP	DEG_APCC_KENBOX_2	0.728
p.V102L	DO229024	LICA	ICGC	IKENP	DEG_APCC_KENBOX_2	0.1111
p.V102L	DO229027	LICA	ICGC	IKENP	DEG_APCC_KENBOX_2	0.1111
p.F86L	DO52669	MALY	ICGC	IKENP	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75496	Geminin	DEG_APCC_KENBOX_2	90:94	IKENP	APC,CDC20,FZR1	0.9695	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons