DegronMD - O95935(TBX18)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H576L	TCGA-05-4390	LUAD	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.25
p.H576L	DO23562	LUAD	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.25
p.V458L	TCGA-21-1076	LUSC	TCGA	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.2778
p.V458L	DO26599	LUSC	ICGC	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.2778
p.P139L	TCGA-43-A56U	LUSC	TCGA	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.2222
p.P383A	TCGA-55-8302	LUAD	TCGA	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.0556
p.P383A	DO45312	LUAD	ICGC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.0556
p.R124S	TCGA-60-2724	LUSC	TCGA	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1944
p.R124S	DO26540	LUSC	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1944
p.G459A	TCGA-62-A471	LUAD	TCGA	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.3056
p.G459A	DO45347	LUAD	ICGC	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.3056
p.S125F	TCGA-66-2791	LUSC	TCGA	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.2222
p.S125F	DO26435	LUSC	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.2222
p.R453K	TCGA-73-4675	LUAD	TCGA	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.1389
p.R453K	TCGA-GS-A9TQ	DLBC	TCGA	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.1389
p.R453K	DO219911	DLBC	ICGC	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.1389
p.R453K	DO23598	LUAD	ICGC	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.1389
p.P139A	TCGA-85-8052	LUSC	TCGA	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.2222
p.P139A	DO26459	LUSC	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.2222
p.M470I	TCGA-90-A4ED	LUSC	TCGA	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.1667
p.M470I	DO45482	LUSC	ICGC	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.1667
p.G145R	TCGA-90-A4ED	LUSC	TCGA	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.0556
p.G145R	DO45482	LUSC	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.0556
p.Q567H	TCGA-A5-A0G2	UCEC	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.647
p.Q567H	DO41235	UCEC	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.647
p.R140Q	TCGA-AA-A022	COAD	TCGA	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1944
p.R140Q	DO10647	COAD	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1944
p.V460M	TCGA-AC-A6NO	BRCA	TCGA	VSSST	DEG_SPOP_SBC_1	460:464	Mutation altering degron motif	0.7208
p.V460M	TCGA-EO-A22U	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	460:464	Mutation altering degron motif	0.7208
p.V460M	DO51206	BRCA	ICGC	VSSST	DEG_SPOP_SBC_1	460:464	Mutation altering degron motif	0.7208
p.V460M	DO43755	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	460:464	Mutation altering degron motif	0.7208
p.P122L	TCGA-AP-A1DV	UCEC	TCGA	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1389
p.G381D	TCGA-AP-A1E1	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1111
p.G381D	DO43226	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1111
p.A127T	TCGA-B5-A1MX	UCEC	TCGA	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.2778
p.A127T	DO41999	UCEC	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.2778
p.A127T	SIDM01617	Endometrial Carcinoma	GDSC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.2778
p.A127T	ACH-000994	Endometrial/Uterine Cancer	CCLE	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.2778
p.P571H	TCGA-BA-6869	HNSC	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.6583
p.P571H	DO14250	HNSC	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.6583
p.Y457F	TCGA-BF-A5EP	SKCM	TCGA	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.25
p.Y457F	DO223906	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.25
p.R128Q	TCGA-C5-A7CK	CESC	TCGA	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.3056
p.R128Q	DO49000	CESC	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.3056
p.R566Q	TCGA-CD-8527	STAD	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.7329
p.R566Q	DO47739	STAD	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.7329
p.T564M	TCGA-CG-4465	STAD	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.3056
p.T564M	TCGA-CG-4474	STAD	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.3056
p.T564M	TCGA-EJ-5494	PRAD	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.3056
p.T564M	DO225278	BRCA	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.3056
p.T564M	DO227844	COCA	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.3056
p.T564M	DO228824	MALY	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.3056
p.T564M	DO36343	PRAD	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.3056
p.T564M	DO38535	STAD	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.3056
p.T564M	DO38627	STAD	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.3056
p.Y457N	TCGA-CG-4476	STAD	TCGA	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.25
p.Y457N	DO38276	STAD	ICGC	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.25
p.G556V	TCGA-D3-A1Q1	SKCM	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.0833
p.G556V	DO37445	SKCM	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.0833
p.G377C	TCGA-D3-A2JC	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.2222
p.G377C	DO47578	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.2222
p.P361S	TCGA-D3-A3C1	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1111
p.R140W	TCGA-D5-6898	COAD	TCGA	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1944
p.R140W	DO10028	COAD	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1944
p.L133V	TCGA-D6-6826	HNSC	TCGA	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.5654
p.P571S	TCGA-EB-A44O	SKCM	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.5641
p.P571S	DO47272	SKCM	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.5641
p.A123V	TCGA-EB-A4XL	SKCM	TCGA	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1667
p.A123V	DO47401	SKCM	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1667
p.P451T	TCGA-EE-A183	SKCM	TCGA	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.0833
p.P451T	DO37715	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.0833
p.G574R	TCGA-FW-A3R5	SKCM	TCGA	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.3056
p.G574R	DO222382	MELA	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.3056
p.G574R	DO37406	SKCM	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.3056
p.V466L	TCGA-OR-A5KB	ACC	TCGA	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.2778
p.G130A	TCGA-V1-A9OX	PRAD	TCGA	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.6429
p.G130A	DO219387	PRAD	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.6429
p.P364S	TCGA-WE-A8K1	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1944
p.P129S	DO225096	BRCA	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.6752
p.V129F	DO225296	BRCA	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.7068
p.A138T	DO227996	COCA	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.25
p.G132R	DO222782	COCA	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.7568
p.S372F	DO223029	ESCA	ICGC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation altering degron motif	0.7982
p.A123E	DO229029	LICA	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1667
p.A138D	DO229024	LICA	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.25
p.A369E	DO229027	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation altering degron motif	0.7701
p.S579R	DO229041	LICA	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation rewiring degron network	0.1667
p.G132W	DO24110	LUAD	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.7825
p.A137G	DO23759	LUAD	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.2778
p.P136T	DO23584	LUAD	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.3056
p.P455L	DO220882	MELA	ICGC	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.1944
p.P134L	DO220891	MELA	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.6471
p.G381R	DO220902	MELA	ICGC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1111
p.G377S	DO50707	ORCA	ICGC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.2222
p.G367R	DO32849	PACA	ICGC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.2778
p.D122G	DO221545	PACA	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1389
p.P139R	DO232677	PBCA	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.2222
p.M568R	DO229459	SKCA	ICGC	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.7521
p.P141Q	DO37651	SKCM	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1667
p.G132V	DO37456	SKCM	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.7532
p.P130L	DO48654	SKCM	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.7582
p.P130L	DO51276	SKCM	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.7582
p.G120E	DO41752	UCEC	ICGC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.0833
p.P570S	SIDM00545	Melanoma	GDSC	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.5641
p.P570S	ACH-000987	Skin Cancer	CCLE	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.5641
p.P570S	Mewo	skin	COSMIC	DRQMLPPVE	DEG_APCC_DBOX_1	565:573	Mutation altering degron motif	0.5641
p.I360M	SIDM01117	Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.0833
p.I360M	ACH-002176	Lung Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.0833
p.I360M	NCI-H748	lung	COSMIC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.0833
p.N380Y	SIDM00555	Glioblastoma	GDSC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1389
p.N380Y	ACH-000631	Brain Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1389
p.N380Y	KS-1	central nervous system	COSMIC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1389
p.V466M	SIDM00193	Colorectal Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.2778
p.V466M	ACH-000991	Colon/Colorectal Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.2778
p.V466M	SNU-81	large intestine	COSMIC	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.2778
p.T464P	SIDM00337	Melanoma	GDSC	VSSST	DEG_SPOP_SBC_1	460:464	Mutation altering degron motif	0.7031
p.N368H	SIDM01140	Ovarian Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.N368H	SIDM00785	Acute Myeloid Leukemia	GDSC	ASSST	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.A450S	SIDM00490	Glioma	GDSC	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.0556
p.A450S	ACH-001016	Brain Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.0556
p.A450S	Becker	central nervous system	COSMIC	VSSST	DEG_SPOP_SBC_1	460:464	Mutation rewiring degron network	0.0556
p.R124L	ACH-001857	Bile Duct Cancer	CCLE	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1944
p.T131P	ACH-001991	Primary	CCLE	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.8142
p.T143S	COR-L32	lung	COSMIC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1111
p.V129I	NCI-H740	lung	COSMIC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.7076
p.S131F	NCI-H1838	lung	COSMIC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.7982
p.A137V	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.2778
p.D122N	SNU-C1	large intestine	COSMIC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1389
p.K136N	ESS-1	endometrium	COSMIC	PGTPLPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TBX18

UniProt ID: O95935

Entrez ID: 9096

Protein name: T-box transcription factor TBX18 (T-box protein 18)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TBX18 in