DegronMD

Uniprot ID: O95935

Source protein: T-box transcription factor TBX18

Source gene: TBX18

Class: DEG_SCF_FBW7_1

Location: 129:135

E3 ligase: FBXW7

DEGRON score: 0.9845

ASA_SCORE: 78.5

COIL: 0.9589

CONS_SCORE: 0.5229

DSS_SCORE: 0.7139

HELIX: 0.0101

FCONS_SCORE: 0.8822

RIG_SCORE: 0.567

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P139L	TCGA-43-A56U	LUSC	TCGA	PGTPLPS	DEG_SCF_FBW7_1	0.2222
p.R124S	TCGA-60-2724	LUSC	TCGA	PGTPLPS	DEG_SCF_FBW7_1	0.1944
p.R124S	DO26540	LUSC	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.1944
p.S125F	TCGA-66-2791	LUSC	TCGA	PGTPLPS	DEG_SCF_FBW7_1	0.2222
p.S125F	DO26435	LUSC	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.2222
p.P139A	TCGA-85-8052	LUSC	TCGA	PGTPLPS	DEG_SCF_FBW7_1	0.2222
p.P139A	DO26459	LUSC	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.2222
p.G145R	TCGA-90-A4ED	LUSC	TCGA	PGTPLPS	DEG_SCF_FBW7_1	0.0556
p.G145R	DO45482	LUSC	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.0556
p.R140Q	TCGA-AA-A022	COAD	TCGA	PGTPLPS	DEG_SCF_FBW7_1	0.1944
p.R140Q	DO10647	COAD	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.1944
p.P122L	TCGA-AP-A1DV	UCEC	TCGA	PGTPLPS	DEG_SCF_FBW7_1	0.1389
p.A127T	TCGA-B5-A1MX	UCEC	TCGA	PGTPLPS	DEG_SCF_FBW7_1	0.2778
p.A127T	DO41999	UCEC	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.2778
p.A127T	SIDM01617	Endometrial Carcinoma	GDSC	PGTPLPS	DEG_SCF_FBW7_1	0.2778
p.A127T	ACH-000994	Endometrial/Uterine Cancer	CCLE	PGTPLPS	DEG_SCF_FBW7_1	0.2778
p.R128Q	TCGA-C5-A7CK	CESC	TCGA	PGTPLPS	DEG_SCF_FBW7_1	0.3056
p.R128Q	DO49000	CESC	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.3056
p.R140W	TCGA-D5-6898	COAD	TCGA	PGTPLPS	DEG_SCF_FBW7_1	0.1944
p.R140W	DO10028	COAD	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.1944
p.L133V	TCGA-D6-6826	HNSC	TCGA	PGTPLPS	DEG_SCF_FBW7_1	0.5654
p.A123V	TCGA-EB-A4XL	SKCM	TCGA	PGTPLPS	DEG_SCF_FBW7_1	0.1667
p.A123V	DO47401	SKCM	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.1667
p.G130A	TCGA-V1-A9OX	PRAD	TCGA	PGTPLPS	DEG_SCF_FBW7_1	0.6429
p.G130A	DO219387	PRAD	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.6429
p.P129S	DO225096	BRCA	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.6752
p.V129F	DO225296	BRCA	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.7068
p.A138T	DO227996	COCA	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.25
p.G132R	DO222782	COCA	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.7568
p.A123E	DO229029	LICA	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.1667
p.A138D	DO229024	LICA	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.25
p.G132W	DO24110	LUAD	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.7825
p.A137G	DO23759	LUAD	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.2778
p.P136T	DO23584	LUAD	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.3056
p.P134L	DO220891	MELA	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.6471
p.D122G	DO221545	PACA	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.1389
p.P139R	DO232677	PBCA	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.2222
p.P141Q	DO37651	SKCM	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.1667
p.G132V	DO37456	SKCM	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.7532
p.P130L	DO48654	SKCM	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.7582
p.P130L	DO51276	SKCM	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.7582
p.G120E	DO41752	UCEC	ICGC	PGTPLPS	DEG_SCF_FBW7_1	0.0833
p.R124L	ACH-001857	Bile Duct Cancer	CCLE	PGTPLPS	DEG_SCF_FBW7_1	0.1944
p.T131P	ACH-001991	Primary	CCLE	PGTPLPS	DEG_SCF_FBW7_1	0.8142
p.T143S	COR-L32	lung	COSMIC	PGTPLPS	DEG_SCF_FBW7_1	0.1111
p.V129I	NCI-H740	lung	COSMIC	PGTPLPS	DEG_SCF_FBW7_1	0.7076
p.S131F	NCI-H1838	lung	COSMIC	PGTPLPS	DEG_SCF_FBW7_1	0.7982
p.A137V	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPLPS	DEG_SCF_FBW7_1	0.2778
p.D122N	SNU-C1	large_intestine	COSMIC	PGTPLPS	DEG_SCF_FBW7_1	0.1389
p.K136N	ESS-1	endometrium	COSMIC	PGTPLPS	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTPLPS

Degron related mutations and impact score

Drug responses associated with TBX18 mutations

All proteins holding degron of PGTPLPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95935	T-box transcription factor TBX18	DEG_SCF_FBW7_1	129:135	PGTPLPS	FBXW7	0.9845	More...