DegronMD

Uniprot ID: O95935

Source protein: T-box transcription factor TBX18

Source gene: TBX18

Class: DEG_SPOP_SBC_1

Location: 460:464

E3 ligase: SPOP

DEGRON score: 0.9891

ASA_SCORE: 60.82

COIL: 0.9358

CONS_SCORE: 0.4813

DSS_SCORE: 0.5104

HELIX: 0.0318

FCONS_SCORE: 0.9034

RIG_SCORE: 0.6687

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V458L	TCGA-21-1076	LUSC	TCGA	VSSST	DEG_SPOP_SBC_1	0.2778
p.V458L	DO26599	LUSC	ICGC	VSSST	DEG_SPOP_SBC_1	0.2778
p.G459A	TCGA-62-A471	LUAD	TCGA	VSSST	DEG_SPOP_SBC_1	0.3056
p.G459A	DO45347	LUAD	ICGC	VSSST	DEG_SPOP_SBC_1	0.3056
p.R453K	TCGA-73-4675	LUAD	TCGA	VSSST	DEG_SPOP_SBC_1	0.1389
p.R453K	TCGA-GS-A9TQ	DLBC	TCGA	VSSST	DEG_SPOP_SBC_1	0.1389
p.R453K	DO219911	DLBC	ICGC	VSSST	DEG_SPOP_SBC_1	0.1389
p.R453K	DO23598	LUAD	ICGC	VSSST	DEG_SPOP_SBC_1	0.1389
p.M470I	TCGA-90-A4ED	LUSC	TCGA	VSSST	DEG_SPOP_SBC_1	0.1667
p.M470I	DO45482	LUSC	ICGC	VSSST	DEG_SPOP_SBC_1	0.1667
p.V460M	TCGA-AC-A6NO	BRCA	TCGA	VSSST	DEG_SPOP_SBC_1	0.7208
p.V460M	TCGA-EO-A22U	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	0.7208
p.V460M	DO51206	BRCA	ICGC	VSSST	DEG_SPOP_SBC_1	0.7208
p.V460M	DO43755	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	0.7208
p.Y457F	TCGA-BF-A5EP	SKCM	TCGA	VSSST	DEG_SPOP_SBC_1	0.25
p.Y457F	DO223906	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	0.25
p.Y457N	TCGA-CG-4476	STAD	TCGA	VSSST	DEG_SPOP_SBC_1	0.25
p.Y457N	DO38276	STAD	ICGC	VSSST	DEG_SPOP_SBC_1	0.25
p.P451T	TCGA-EE-A183	SKCM	TCGA	VSSST	DEG_SPOP_SBC_1	0.0833
p.P451T	DO37715	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	0.0833
p.V466L	TCGA-OR-A5KB	ACC	TCGA	VSSST	DEG_SPOP_SBC_1	0.2778
p.P455L	DO220882	MELA	ICGC	VSSST	DEG_SPOP_SBC_1	0.1944
p.V466M	SIDM00193	Colorectal Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.2778
p.V466M	ACH-000991	Colon/Colorectal Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	0.2778
p.V466M	SNU-81	large_intestine	COSMIC	VSSST	DEG_SPOP_SBC_1	0.2778
p.T464P	SIDM00337	Melanoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.7031
p.A450S	SIDM00490	Glioma	GDSC	VSSST	DEG_SPOP_SBC_1	0.0556
p.A450S	ACH-001016	Brain Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	0.0556
p.A450S	Becker	central_nervous_system	COSMIC	VSSST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60237	Protein phosphatase 1 regulatory subunit 12B	DEG_SPOP_SBC_1	574:578	VSSST	SPOP	0.9726	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2573:2577	VSSST	SPOP	0.768	More...
O75496	Geminin	DEG_SPOP_SBC_1	199:203	VSSST	SPOP	0.9991	More...
O95935	T-box transcription factor TBX18	DEG_SPOP_SBC_1	460:464	VSSST	SPOP	0.9891	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1797:1801	VSSST	SPOP	0.9347	More...
Q12951	Forkhead box protein I1	DEG_SPOP_SBC_1	222:226	VSSST	SPOP	0.9895	More...
Q13433	Zinc transporter ZIP6	DEG_SPOP_SBC_1	218:222	VSSST	SPOP	0.9963	More...
Q13516	Oligodendrocyte transcription factor 2	DEG_SPOP_SBC_1	39:43	VSSST	SPOP	0.9992	More...
Q2LD37	Transmembrane protein KIAA1109	DEG_SPOP_SBC_1	4029:4033	VSSST	SPOP	0.5866	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	5734:5738	VSSST	SPOP	0.9977	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2933:2937	VSSST	SPOP	0.996	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	1005:1009	VSSST	SPOP	0.9988	More...
Q8NEZ2	Vacuolar protein sorting-associated protein 37A	DEG_SPOP_SBC_1	179:183	VSSST	SPOP	0.9741	More...
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	835:839	VSSST	SPOP	0.9941	More...
Q96IZ0	PRKC apoptosis WT1 regulator protein	DEG_SPOP_SBC_1	263:267	VSSST	SPOP	0.7604	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	155:159	VSSST	SPOP	0.9548	More...
Q9UJT9	F-box/LRR-repeat protein 7	DEG_SPOP_SBC_1	23:27	VSSST	SPOP	0.9977	More...
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_SPOP_SBC_1	659:663	VSSST	SPOP	0.9709	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	365:369	VSSST	SPOP	0.9057	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSSST

Degron related mutations and impact score

Drug responses associated with TBX18 mutations

All proteins holding degron of VSSST