DegronMD - Q9UJT9(FBXL7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A39P	TCGA-38-4631	LUAD	TCGA	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation rewiring degron network	0.1667
p.A39P	DO24970	LUAD	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation rewiring degron network	0.1667
p.T30M	TCGA-BR-7851	STAD	TCGA	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation altering degron motif	0.8534
p.E42K	TCGA-BS-A0UF	UCEC	TCGA	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation rewiring degron network	0.0833
p.E42K	DO41488	UCEC	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation rewiring degron network	0.0833
p.S21P	TCGA-CD-8536	STAD	TCGA	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation rewiring degron network	0.1944
p.S21P	TCGA-CD-8536	STAD	TCGA	VSSST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.2778
p.K33E	TCGA-CV-6935	HNSC	TCGA	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation altering degron motif	0.7022
p.Q35K	TCGA-FS-A1Z4	SKCM	TCGA	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation rewiring degron network	0.2778
p.Q35K	TCGA-FS-A1Z4	SKCM	TCGA	VSSST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1111
p.S25L	TCGA-YD-A89C	SKCM	TCGA	VSSST	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.7667
p.S29F	DO558	BLCA	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation altering degron motif	0.7982
p.H42P	DO228643	GACA	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation rewiring degron network	0.0833
p.G13C	DO228948	LICA	ICGC	VSSST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0556
p.S41I	DO228986	LICA	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation rewiring degron network	0.1111
p.I19V	DO231782	LINC	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation rewiring degron network	0.1389
p.I19V	DO231782	LINC	ICGC	VSSST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.2222
p.S32Y	DO24409	LUAD	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation altering degron motif	0.712
p.T37M	DO228526	MALY	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation rewiring degron network	0.2222
p.T37M	DO228526	MALY	ICGC	VSSST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0556
p.T37M	DO47915	STAD	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation rewiring degron network	0.2222
p.T37M	DO47915	STAD	ICGC	VSSST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0556
p.T37M	DO41361	UCEC	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation rewiring degron network	0.2222
p.T37M	DO41361	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0556
p.T37M	CW-2	large intestine	COSMIC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation rewiring degron network	0.2222
p.T37M	CW-2	large intestine	COSMIC	VSSST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0556
p.E30Q	DO222818	MELA	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation altering degron motif	0.6744
p.T15A	DO229149	NKTL	ICGC	VSSST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1111
p.P18S	DO27943	ORCA	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation rewiring degron network	0.1111
p.P18S	DO27943	ORCA	ICGC	VSSST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.Q23K	DO37462	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.6944
p.S13L	DO219501	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0556
p.M40V	DO38192	STAD	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation rewiring degron network	0.1389
p.A34S	SIDM00823	Colorectal Carcinoma	GDSC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation rewiring degron network	0.3056
p.A34S	SIDM00823	Colorectal Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1389
p.T42M	CW-2	large intestine	COSMIC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation rewiring degron network	0.0833
p.G25S	HCT-15	large intestine	COSMIC	VSSST	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.6993
p.I17M	KMRC-1	kidney	COSMIC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation rewiring degron network	0.0833
p.I17M	KMRC-1	kidney	COSMIC	VSSST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1667
p.G30S	HCT-15	large intestine	COSMIC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation altering degron motif	0.6993
p.G25C	CAL-12T	lung	COSMIC	VSSST	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.76
p.G30C	CAL-12T	lung	COSMIC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	26:33	Mutation altering degron motif	0.76

Kaplan plot for FBXL7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FBXL7

UniProt ID: Q9UJT9

Entrez ID: 23194

Protein name: F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FBXL7 in