DegronMD

Uniprot ID: Q9UJT9

Source protein: F-box/LRR-repeat protein 7

Source gene: FBXL7

Class: DEG_SCF_SKP2-CKS1_1

Location: 26:33

E3 ligase: SKP2,CSK1

DEGRON score: 0.9818

ASA_SCORE: 97.5625

COIL: 0.8424

CONS_SCORE: 0.2727

DSS_SCORE: 0.6389

HELIX: 0.1425

FCONS_SCORE: 0.9338

RIG_SCORE: 0.6129

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A39P	TCGA-38-4631	LUAD	TCGA	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.1667
p.A39P	DO24970	LUAD	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.1667
p.T30M	TCGA-BR-7851	STAD	TCGA	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.8534
p.E42K	TCGA-BS-A0UF	UCEC	TCGA	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.0833
p.E42K	DO41488	UCEC	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.0833
p.S21P	TCGA-CD-8536	STAD	TCGA	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.1944
p.K33E	TCGA-CV-6935	HNSC	TCGA	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.7022
p.Q35K	TCGA-FS-A1Z4	SKCM	TCGA	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.2778
p.S29F	DO558	BLCA	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.7982
p.H42P	DO228643	GACA	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.0833
p.S41I	DO228986	LICA	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.1111
p.I19V	DO231782	LINC	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S32Y	DO24409	LUAD	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.712
p.T37M	DO228526	MALY	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.2222
p.T37M	DO47915	STAD	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.2222
p.T37M	DO41361	UCEC	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.2222
p.T37M	CW-2	large_intestine	COSMIC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.2222
p.E30Q	DO222818	MELA	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.6744
p.P18S	DO27943	ORCA	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.1111
p.M40V	DO38192	STAD	ICGC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.1389
p.A34S	SIDM00823	Colorectal Carcinoma	GDSC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.3056
p.T42M	CW-2	large_intestine	COSMIC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.0833
p.I17M	KMRC-1	kidney	COSMIC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.0833
p.G30S	HCT-15	large_intestine	COSMIC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.6993
p.G30C	CAL-12T	lung	COSMIC	STDHTPTK	DEG_SCF_SKP2-CKS1_1	0.76

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJT9	F-box/LRR-repeat protein 7	DEG_SCF_SKP2-CKS1_1	26:33	STDHTPTK	SKP2,CSK1	0.9818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: STDHTPTK

Degron related mutations and impact score

Drug responses associated with FBXL7 mutations

All proteins holding degron of STDHTPTK