DegronMD - Q12951(FOXI1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R216G	TCGA-05-4382	LUAD	TCGA	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.1667
p.R216G	DO24900	LUAD	ICGC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.1667
p.R216G	SIDM01608	Endometrial Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.1667
p.R216G	ACH-000990	Endometrial/Uterine Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.1667
p.R213C	TCGA-28-2509	GBM	TCGA	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.0833
p.R213C	TCGA-B5-A1MR	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.0833
p.R213C	TCGA-EB-A85J	SKCM	TCGA	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.0833
p.R213C	DO10882	GBM	ICGC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.0833
p.R213C	DO50297	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.0833
p.R213C	DO41758	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.0833
p.R216S	TCGA-44-2657	LUAD	TCGA	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.1667
p.R216S	DO25020	LUAD	ICGC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.1667
p.G313W	TCGA-44-8117	LUAD	TCGA	PLVTPGLS	DEG_SCF_FBW7_1	298:305	Mutation rewiring degron network	0.1111
p.G313W	DO229018	LICA	ICGC	PLVTPGLS	DEG_SCF_FBW7_1	298:305	Mutation rewiring degron network	0.1111
p.G313W	DO24028	LUAD	ICGC	PLVTPGLS	DEG_SCF_FBW7_1	298:305	Mutation rewiring degron network	0.1111
p.P94L	TCGA-AA-3492	COAD	TCGA	QRPLLPSVS	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.6471
p.P94L	DO8224	COAD	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.6471
p.E33D	TCGA-AA-A010	COAD	TCGA	MNLYYE	LIG_APCC_ABBA_1	28:33	Mutation altering degron motif	0.5647
p.L107M	TCGA-AX-A2HD	UCEC	TCGA	QRPLLPSVS	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.1389
p.L107M	DO42608	UCEC	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.1389
p.S43G	TCGA-BG-A222	UCEC	TCGA	MNLYYE	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.0556
p.S43G	DO42977	UCEC	ICGC	MNLYYE	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.0556
p.A227T	TCGA-BG-A222	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.3056
p.A227T	DO42977	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.3056
p.E27K	TCGA-BR-4191	STAD	TCGA	MNLYYE	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.3056
p.E27K	DO38891	STAD	ICGC	MNLYYE	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.3056
p.P72T	TCGA-CM-6674	COAD	TCGA	PPPY	ITCH	72:75	Mutation altering degron motif	0.7031
p.P72T	DO10092	COAD	ICGC	PPPY	ITCH	72:75	Mutation altering degron motif	0.7031
p.P298L	TCGA-D3-A3MR	SKCM	TCGA	PLVTPGLS	DEG_SCF_FBW7_1	298:305	Mutation altering degron motif	0.6471
p.P298L	DO47256	SKCM	ICGC	PLVTPGLS	DEG_SCF_FBW7_1	298:305	Mutation altering degron motif	0.6471
p.G78S	TCGA-D5-6924	COAD	TCGA	PPPY	ITCH	72:75	Mutation rewiring degron network	0.25
p.G78S	DO7922	COAD	ICGC	PPPY	ITCH	72:75	Mutation rewiring degron network	0.25
p.R213H	TCGA-DQ-5631	HNSC	TCGA	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.0833
p.R213H	DO14175	HNSC	ICGC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.0833
p.P306H	TCGA-DU-6392	LGG	TCGA	PLVTPGLS	DEG_SCF_FBW7_1	298:305	Mutation rewiring degron network	0.3056
p.P306H	DO22237	LGG	ICGC	PLVTPGLS	DEG_SCF_FBW7_1	298:305	Mutation rewiring degron network	0.3056
p.S309R	TCGA-FS-A1ZW	SKCM	TCGA	PLVTPGLS	DEG_SCF_FBW7_1	298:305	Mutation rewiring degron network	0.2222
p.S309R	DO37519	SKCM	ICGC	PLVTPGLS	DEG_SCF_FBW7_1	298:305	Mutation rewiring degron network	0.2222
p.M28I	TCGA-FW-A3R5	SKCM	TCGA	MNLYYE	LIG_APCC_ABBA_1	28:33	Mutation altering degron motif	0.6507
p.M28I	TCGA-QQ-A8VG	SARC	TCGA	MNLYYE	LIG_APCC_ABBA_1	28:33	Mutation altering degron motif	0.6507
p.M28I	DO220260	SARC	ICGC	MNLYYE	LIG_APCC_ABBA_1	28:33	Mutation altering degron motif	0.6507
p.M28I	DO37406	SKCM	ICGC	MNLYYE	LIG_APCC_ABBA_1	28:33	Mutation altering degron motif	0.6507
p.L102F	TCGA-IB-7651	PAAD	TCGA	QRPLLPSVS	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.2778
p.L102F	DO46657	PAAD	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.2778
p.E24Q	TCGA-IB-AAUQ	PAAD	TCGA	MNLYYE	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.2222
p.E24Q	DO51705	PAAD	ICGC	MNLYYE	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.2222
p.Y75H	TCGA-L5-A8NM	ESCA	TCGA	PPPY	ITCH	72:75	Mutation altering degron motif	0.7229
p.S43I	TCGA-OR-A5KB	ACC	TCGA	MNLYYE	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.0556
p.G101R	DO1076	BRCA	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.3056
p.G104W	DO222608	BTCA	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.2222
p.G104V	DO222608	BTCA	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	92:100	Mutation rewiring degron network	0.2222
p.S305G	DO230312	COCA	ICGC	PLVTPGLS	DEG_SCF_FBW7_1	298:305	Mutation altering degron motif	0.6993
p.V99M	DO222849	COCA	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.6097
p.G313R	DO50454	ESAD	ICGC	PLVTPGLS	DEG_SCF_FBW7_1	298:305	Mutation rewiring degron network	0.1111
p.S100L	DO14814	HNSC	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.6556
p.S100L	DO33232	PACA	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.6556
p.S100L	DO229446	SKCA	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.6556
p.L95Q	DO228949	LICA	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.6654
p.A227S	DO228948	LICA	ICGC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.3056
p.S20I	DO229045	LICA	ICGC	MNLYYE	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.1111
p.P26S	DO50750	LICA	ICGC	MNLYYE	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.2778
p.P72Q	DO23232	LINC	ICGC	PPPY	ITCH	72:75	Mutation altering degron motif	0.7035
p.P302L	DO222875	MELA	ICGC	PLVTPGLS	DEG_SCF_FBW7_1	298:305	Mutation altering degron motif	0.7582
p.P68S	SIDM00994	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	72:75	Mutation rewiring degron network	0.2222
p.P68S	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	72:75	Mutation rewiring degron network	0.2222
p.Q92K	SIDM00697	Small Cell Lung Carcinoma	GDSC	QRPLLPSVS	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.5833
p.T226I	SIDM01080	Oral Cavity Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7078
p.T226I	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7078
p.T226I	SIDM01716	Non-Cancerous	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7078
p.T226I	SIDM00175	Melanoma	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7078
p.T226I	SIDM00892	Breast Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7078
p.T226I	SIDM00542	Glioblastoma	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7078
p.T226I	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7078
p.T226I	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7078
p.T226I	SIDM01700	Hodgkin's Lymphoma	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7078
p.D221H	SIDM00566	Oral Cavity Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.3056
p.D221H	ACH-001625	Head and Neck Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.3056
p.D221H	OSC-19	upper aerodigestive tract	COSMIC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.3056
p.Y32C	SIDM01609	Endometrial Carcinoma	GDSC	MNLYYE	LIG_APCC_ABBA_1	28:33	Mutation altering degron motif	0.5976
p.Y32C	ACH-000972	Endometrial/Uterine Cancer	CCLE	MNLYYE	LIG_APCC_ABBA_1	28:33	Mutation altering degron motif	0.5976
p.S236N	SIDM00634	Ewing's Sarcoma	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.0556
p.S236N	ACH-000039	Bone Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.0556
p.P79R	ACH-000760	Brain Cancer	CCLE	PPPY	ITCH	72:75	Mutation rewiring degron network	0.2222
p.S43R	ACH-000872	Lung Cancer	CCLE	MNLYYE	LIG_APCC_ABBA_1	28:33	Mutation rewiring degron network	0.0556
p.S309T	ACH-000884	Skin Cancer	CCLE	PLVTPGLS	DEG_SCF_FBW7_1	298:305	Mutation rewiring degron network	0.2222
p.P72R	ACH-001786	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	72:75	Mutation altering degron motif	0.7512
p.T223S	HCT-116	large intestine	COSMIC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7116

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOXI1

UniProt ID: Q12951

Entrez ID: 2299

Protein name: Forkhead box protein I1 (Forkhead-related protein FKHL10) (Forkhead-related transcription factor 6) (FREAC-6) (Hepatocyte nuclear factor 3 forkhead homolog 3) (HFH-3) (HNF-3/fork-head homolog 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOXI1 in