DegronMD - Q12951(FOXI1)

FUNCTION: Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity). {ECO:0000250}.

GO - Biological processes (BP): anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; embryo development ending in birth or egg hatching [GO:0009792]; inner ear morphogenesis [GO:0042472]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polyme... View more >>

GO - Molecular function (MF): DNA binding, bending [GO:0008301]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II cis-regulatory regio... View more >>

GO - Cellular component (CC): chromatin [GO:0000785]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P302L	DO222875	MELA	ICGC	PLVTPGLS	DEG_SCF_FBW7_1	298:305	Mutation altering degron motif	0.7582
p.P72R	ACH-001786	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	72:75	Mutation altering degron motif	0.7512
p.Y75H	TCGA-L5-A8NM	ESCA	TCGA	PPPY	ITCH	72:75	Mutation altering degron motif	0.7229
p.T223S	HCT-116	large intestine	COSMIC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7116
p.T226I	SIDM01080	Oral Cavity Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7078
p.T226I	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7078
p.T226I	SIDM01716	Non-Cancerous	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7078
p.T226I	SIDM00175	Melanoma	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7078
p.T226I	SIDM00892	Breast Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7078
p.T226I	SIDM00542	Glioblastoma	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7078
p.T226I	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7078
p.T226I	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7078
p.T226I	SIDM01700	Hodgkin's Lymphoma	GDSC	VSSST	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7078
p.P72Q	DO23232	LINC	ICGC	PPPY	ITCH	72:75	Mutation altering degron motif	0.7035
p.P72T	TCGA-CM-6674	COAD	TCGA	PPPY	ITCH	72:75	Mutation altering degron motif	0.7031
p.P72T	DO10092	COAD	ICGC	PPPY	ITCH	72:75	Mutation altering degron motif	0.7031
p.S305G	DO230312	COCA	ICGC	PLVTPGLS	DEG_SCF_FBW7_1	298:305	Mutation altering degron motif	0.6993
p.L95Q	DO228949	LICA	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.6654
p.S100L	DO14814	HNSC	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.6556
p.S100L	DO33232	PACA	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	92:100	Mutation altering degron motif	0.6556

Showing 1 to 20 of 87 entries

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Kaplan plot for FOXI1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOXI1

UniProt ID: Q12951

Entrez ID: 2299

Protein name: Forkhead box protein I1 (Forkhead-related protein FKHL10) (Forkhead-related transcription factor 6) (FREAC-6) (Hepatocyte nuclear factor 3 forkhead homolog 3) (HFH-3) (HNF-3/fork-head homolog 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOXI1 in