DegronMD

Uniprot ID: Q12951

Source protein: Forkhead box protein I1

Source gene: FOXI1

Class: LIG_APCC_ABBA_1

Location: 28:33

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7078

ASA_SCORE: 53.9

COIL: 0.631

CONS_SCORE: 0.5203

DSS_SCORE: 0.5622

HELIX: 0.236

FCONS_SCORE: 0.8982

RIG_SCORE: 0.7533

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E33D	TCGA-AA-A010	COAD	TCGA	MNLYYE	LIG_APCC_ABBA_1	0.5647
p.S43G	TCGA-BG-A222	UCEC	TCGA	MNLYYE	LIG_APCC_ABBA_1	0.0556
p.S43G	DO42977	UCEC	ICGC	MNLYYE	LIG_APCC_ABBA_1	0.0556
p.E27K	TCGA-BR-4191	STAD	TCGA	MNLYYE	LIG_APCC_ABBA_1	0.3056
p.E27K	DO38891	STAD	ICGC	MNLYYE	LIG_APCC_ABBA_1	0.3056
p.M28I	TCGA-FW-A3R5	SKCM	TCGA	MNLYYE	LIG_APCC_ABBA_1	0.6507
p.M28I	TCGA-QQ-A8VG	SARC	TCGA	MNLYYE	LIG_APCC_ABBA_1	0.6507
p.M28I	DO220260	SARC	ICGC	MNLYYE	LIG_APCC_ABBA_1	0.6507
p.M28I	DO37406	SKCM	ICGC	MNLYYE	LIG_APCC_ABBA_1	0.6507
p.E24Q	TCGA-IB-AAUQ	PAAD	TCGA	MNLYYE	LIG_APCC_ABBA_1	0.2222
p.E24Q	DO51705	PAAD	ICGC	MNLYYE	LIG_APCC_ABBA_1	0.2222
p.S43I	TCGA-OR-A5KB	ACC	TCGA	MNLYYE	LIG_APCC_ABBA_1	0.0556
p.S20I	DO229045	LICA	ICGC	MNLYYE	LIG_APCC_ABBA_1	0.1111
p.P26S	DO50750	LICA	ICGC	MNLYYE	LIG_APCC_ABBA_1	0.2778
p.Y32C	SIDM01609	Endometrial Carcinoma	GDSC	MNLYYE	LIG_APCC_ABBA_1	0.5976
p.Y32C	ACH-000972	Endometrial/Uterine Cancer	CCLE	MNLYYE	LIG_APCC_ABBA_1	0.5976
p.S43R	ACH-000872	Lung Cancer	CCLE	MNLYYE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12951	Forkhead box protein I1	LIG_APCC_ABBA_1	28:33	MNLYYE	APC,CDC20,FZR1	0.7078	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons