DegronMD

Uniprot ID: Q12951

Source protein: Forkhead box protein I1

Source gene: FOXI1

Class: DEG_SCF_FBW7_1

Location: 298:305

E3 ligase: FBXW7

DEGRON score: 0.9938

ASA_SCORE: 72.6875

COIL: 0.9414

CONS_SCORE: 0.5412

DSS_SCORE: 0.6663

HELIX: 0.0123

FCONS_SCORE: 0.9964

RIG_SCORE: 0.6338

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G313W	TCGA-44-8117	LUAD	TCGA	PLVTPGLS	DEG_SCF_FBW7_1	0.1111
p.G313W	DO229018	LICA	ICGC	PLVTPGLS	DEG_SCF_FBW7_1	0.1111
p.G313W	DO24028	LUAD	ICGC	PLVTPGLS	DEG_SCF_FBW7_1	0.1111
p.P298L	TCGA-D3-A3MR	SKCM	TCGA	PLVTPGLS	DEG_SCF_FBW7_1	0.6471
p.P298L	DO47256	SKCM	ICGC	PLVTPGLS	DEG_SCF_FBW7_1	0.6471
p.P306H	TCGA-DU-6392	LGG	TCGA	PLVTPGLS	DEG_SCF_FBW7_1	0.3056
p.P306H	DO22237	LGG	ICGC	PLVTPGLS	DEG_SCF_FBW7_1	0.3056
p.S309R	TCGA-FS-A1ZW	SKCM	TCGA	PLVTPGLS	DEG_SCF_FBW7_1	0.2222
p.S309R	DO37519	SKCM	ICGC	PLVTPGLS	DEG_SCF_FBW7_1	0.2222
p.S305G	DO230312	COCA	ICGC	PLVTPGLS	DEG_SCF_FBW7_1	0.6993
p.G313R	DO50454	ESAD	ICGC	PLVTPGLS	DEG_SCF_FBW7_1	0.1111
p.P302L	DO222875	MELA	ICGC	PLVTPGLS	DEG_SCF_FBW7_1	0.7582
p.S309T	ACH-000884	Skin Cancer	CCLE	PLVTPGLS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12951	Forkhead box protein I1	DEG_SCF_FBW7_1	298:305	PLVTPGLS	FBXW7	0.9938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons