DegronMD

Uniprot ID: Q12951

Source protein: Forkhead box protein I1

Source gene: FOXI1

Class: DEG_APCC_DBOX_1

Location: 92:100

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9352

ASA_SCORE: 73.4333

COIL: 0.8761

CONS_SCORE: 0.5528

DSS_SCORE: 0.3168

HELIX: 0.0572

FCONS_SCORE: 0.9598

RIG_SCORE: 0.7298

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P94L	TCGA-AA-3492	COAD	TCGA	QRPLLPSVS	DEG_APCC_DBOX_1	0.6471
p.P94L	DO8224	COAD	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	0.6471
p.L107M	TCGA-AX-A2HD	UCEC	TCGA	QRPLLPSVS	DEG_APCC_DBOX_1	0.1389
p.L107M	DO42608	UCEC	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	0.1389
p.L102F	TCGA-IB-7651	PAAD	TCGA	QRPLLPSVS	DEG_APCC_DBOX_1	0.2778
p.L102F	DO46657	PAAD	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	0.2778
p.G101R	DO1076	BRCA	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	0.3056
p.G104W	DO222608	BTCA	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	0.2222
p.G104V	DO222608	BTCA	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	0.2222
p.V99M	DO222849	COCA	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	0.6097
p.S100L	DO14814	HNSC	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	0.6556
p.S100L	DO33232	PACA	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	0.6556
p.S100L	DO229446	SKCA	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	0.6556
p.L95Q	DO228949	LICA	ICGC	QRPLLPSVS	DEG_APCC_DBOX_1	0.6654
p.Q92K	SIDM00697	Small Cell Lung Carcinoma	GDSC	QRPLLPSVS	DEG_APCC_DBOX_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12951	Forkhead box protein I1	DEG_APCC_DBOX_1	92:100	QRPLLPSVS	APC,CDC20,FZR1	0.9352	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons