DegronMD - Q9Y6Q9(NCOA3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1051I	TCGA-06-0221	GBM	TCGA	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation altering degron motif	0.8102
p.R1051I	DO13971	GBM	ICGC	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation altering degron motif	0.8102
p.S669C	TCGA-91-A4BC	LUAD	TCGA	VSSTS	DEG_SPOP_SBC_1	667:671	Mutation altering degron motif	0.7541
p.S669C	DO45422	LUAD	ICGC	VSSTS	DEG_SPOP_SBC_1	667:671	Mutation altering degron motif	0.7541
p.L1060F	TCGA-A7-A26H	BRCA	TCGA	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation rewiring degron network	0.2778
p.R1031M	TCGA-AA-3966	COAD	TCGA	LRNSLDDLV	DEG_APCC_DBOX_1	1030:1038	Mutation altering degron motif	0.8632
p.D1049Y	TCGA-AB-2806	LAML	TCGA	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation rewiring degron network	0.3056
p.D1049Y	DO21283	LAML	ICGC	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation rewiring degron network	0.3056
p.V721A	TCGA-AP-A1DV	UCEC	TCGA	KKENN	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.0556
p.R744T	TCGA-BK-A139	UCEC	TCGA	KKENN	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.0833
p.S671C	TCGA-C5-A1BK	CESC	TCGA	VSSTS	DEG_SPOP_SBC_1	667:671	Mutation altering degron motif	0.7541
p.Q724H	TCGA-DD-AAVX	LIHC	TCGA	KKENN	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.1389
p.S662C	TCGA-G2-AA3D	BLCA	TCGA	VSSST	DEG_SPOP_SBC_1	659:663	Mutation altering degron motif	0.7541
p.S672C	DO51884	BLCA	ICGC	VSSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.0833
p.S672C	DO51884	BLCA	ICGC	VSSTS	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.3056
p.L741P	DO1209	BRCA	ICGC	KKENN	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.1667
p.Q736H	DO1127	BRCA	ICGC	KKENN	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.3056
p.S681C	DO6266	CESC	ICGC	VSSTS	DEG_SPOP_SBC_1	667:671	Mutation substituting flanking lysine	0.1667
p.S725F	DO15286	HNSC	ICGC	KKENN	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.1667
p.R739I	DO228924	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.2222
p.A1024S	DO229032	LICA	ICGC	LRNSLDDLV	DEG_APCC_DBOX_1	1030:1038	Mutation rewiring degron network	0.1667
p.A1024S	DO229045	LICA	ICGC	LRNSLDDLV	DEG_APCC_DBOX_1	1030:1038	Mutation rewiring degron network	0.1667
p.Q734H	DO52283	LIHC	ICGC	KKENN	DEG_APCC_KENBOX_2	731:735	Mutation altering degron motif	0.7582
p.G1042V	DO23564	LUAD	ICGC	LRNSLDDLV	DEG_APCC_DBOX_1	1030:1038	Mutation blocking phosphorylation signal	0.6667
p.G1042V	DO23564	LUAD	ICGC	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation blocking phosphorylation signal	0.5556
p.P651L	DO222710	MELA	ICGC	VSSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1111
p.L737R	DO221545	PACA	ICGC	KKENN	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.2778
p.G729R	DO35735	PBCA	ICGC	KKENN	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.2778
p.G729R	DO229502	SKCA	ICGC	KKENN	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.2778
p.S654L	DO51275	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1944
p.S1033Y	DO229245	THCA	ICGC	LRNSLDDLV	DEG_APCC_DBOX_1	1030:1038	Mutation altering degron motif	0.712
p.V731A	DO43186	UCEC	ICGC	KKENN	DEG_APCC_KENBOX_2	731:735	Mutation altering degron motif	0.6936
p.Q1025E	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	LRNSLDDLV	DEG_APCC_DBOX_1	1030:1038	Mutation rewiring degron network	0.1944
p.Q1025E	ACH-002157	Lung Cancer	CCLE	LRNSLDDLV	DEG_APCC_DBOX_1	1030:1038	Mutation rewiring degron network	0.1944
p.Q1025E	LC-2-ad	lung	COSMIC	LRNSLDDLV	DEG_APCC_DBOX_1	1030:1038	Mutation rewiring degron network	0.1944
p.S657F	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.2778
p.S657F	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.0556
p.S657F	ACH-000824	Esophageal Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.2778
p.S657F	ACH-000824	Esophageal Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.0556
p.S657F	KYSE-510	oesophagus	COSMIC	VSSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.2778
p.S657F	KYSE-510	oesophagus	COSMIC	VSSTS	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.0556
p.P1028S	SIDM00282	Colorectal Carcinoma	GDSC	LRNSLDDLV	DEG_APCC_DBOX_1	1030:1038	Mutation rewiring degron network	0.2778
p.L1044M	SIDM00874	Breast Carcinoma	GDSC	LRNSLDDLV	DEG_APCC_DBOX_1	1030:1038	Mutation rewiring degron network	0.1667
p.L1044M	SIDM00874	Breast Carcinoma	GDSC	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation rewiring degron network	0.1667
p.L1044M	ACH-000223	Breast Cancer	CCLE	LRNSLDDLV	DEG_APCC_DBOX_1	1030:1038	Mutation rewiring degron network	0.1667
p.L1044M	ACH-000223	Breast Cancer	CCLE	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation rewiring degron network	0.1667
p.L1044M	HCC1937	breast	COSMIC	LRNSLDDLV	DEG_APCC_DBOX_1	1030:1038	Mutation rewiring degron network	0.1667
p.L1044M	HCC1937	breast	COSMIC	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation rewiring degron network	0.1667
p.T1059A	SIDM00181	Bladder Carcinoma	GDSC	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation blocking phosphorylation signal	0.75
p.T1059A	ACH-002266	Bladder Cancer	CCLE	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation blocking phosphorylation signal	0.75
p.T1059A	LB831-BLC	urinary tract	COSMIC	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation blocking phosphorylation signal	0.75
p.V721I	SIDM01220	Glioma	GDSC	KKENN	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.0556
p.V721I	LNZTA3WT4	central nervous system	COSMIC	KKENN	DEG_APCC_KENBOX_2	731:735	Mutation rewiring degron network	0.0556
p.T1059N	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation blocking phosphorylation signal	0.75
p.T1059N	ACH-000873	Esophageal Cancer	CCLE	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation blocking phosphorylation signal	0.75
p.T1059N	KYSE-270	oesophagus	COSMIC	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation blocking phosphorylation signal	0.75
p.E1050K	SIDM00118	Colorectal Carcinoma	GDSC	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation altering degron motif	0.591
p.E1050K	ACH-001081	Colon/Colorectal Cancer	CCLE	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation altering degron motif	0.591
p.E1050K	HCC2998	large intestine	COSMIC	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation altering degron motif	0.591
p.E1045K	HCC2998	large intestine	COSMIC	LRNSLDDLV	DEG_APCC_DBOX_1	1030:1038	Mutation rewiring degron network	0.1389
p.E1045K	HCC2998	large intestine	COSMIC	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation rewiring degron network	0.1944
p.T1054N	KYSE-270	oesophagus	COSMIC	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation altering degron motif	0.7055
p.Q1020E	LC-2-ad	lung	COSMIC	LRNSLDDLV	DEG_APCC_DBOX_1	1030:1038	Mutation rewiring degron network	0.0556
p.V731I	LNZTA3WT4	central nervous system	COSMIC	KKENN	DEG_APCC_KENBOX_2	731:735	Mutation altering degron motif	0.7076
p.S667F	KYSE-510	oesophagus	COSMIC	VSSTS	DEG_SPOP_SBC_1	667:671	Mutation altering degron motif	0.7982
p.P651S	OVK-18	ovary	COSMIC	VSSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1111
p.L1039M	HCC1937	breast	COSMIC	LRNSLDDLV	DEG_APCC_DBOX_1	1030:1038	Mutation rewiring degron network	0.3056
p.T1054A	LB831-BLC	urinary tract	COSMIC	ERALLDQLH	DEG_APCC_DBOX_1	1050:1058	Mutation altering degron motif	0.7139

Kaplan plot for NCOA3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NCOA3

UniProt ID: Q9Y6Q9

Entrez ID: 8202

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NCOA3 in