DegronMD

Uniprot ID: Q9Y6Q9

Source protein: Nuclear receptor coactivator 3

Source gene: NCOA3

Class: DEG_APCC_DBOX_1

Location: 1030:1038

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9955

ASA_SCORE: 84.2556

COIL: 0.7899

CONS_SCORE: 0.5539

DSS_SCORE: 0.5784

HELIX: 0.1833

FCONS_SCORE: 1.0531

RIG_SCORE: 0.7053

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1031M	TCGA-AA-3966	COAD	TCGA	LRNSLDDLV	DEG_APCC_DBOX_1	0.8632
p.A1024S	DO229032	LICA	ICGC	LRNSLDDLV	DEG_APCC_DBOX_1	0.1667
p.A1024S	DO229045	LICA	ICGC	LRNSLDDLV	DEG_APCC_DBOX_1	0.1667
p.G1042V	DO23564	LUAD	ICGC	LRNSLDDLV	DEG_APCC_DBOX_1	0.6667
p.S1033Y	DO229245	THCA	ICGC	LRNSLDDLV	DEG_APCC_DBOX_1	0.712
p.Q1025E	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	LRNSLDDLV	DEG_APCC_DBOX_1	0.1944
p.Q1025E	ACH-002157	Lung Cancer	CCLE	LRNSLDDLV	DEG_APCC_DBOX_1	0.1944
p.Q1025E	LC-2-ad	lung	COSMIC	LRNSLDDLV	DEG_APCC_DBOX_1	0.1944
p.P1028S	SIDM00282	Colorectal Carcinoma	GDSC	LRNSLDDLV	DEG_APCC_DBOX_1	0.2778
p.L1044M	SIDM00874	Breast Carcinoma	GDSC	LRNSLDDLV	DEG_APCC_DBOX_1	0.1667
p.L1044M	ACH-000223	Breast Cancer	CCLE	LRNSLDDLV	DEG_APCC_DBOX_1	0.1667
p.L1044M	HCC1937	breast	COSMIC	LRNSLDDLV	DEG_APCC_DBOX_1	0.1667
p.E1045K	HCC2998	large_intestine	COSMIC	LRNSLDDLV	DEG_APCC_DBOX_1	0.1389
p.Q1020E	LC-2-ad	lung	COSMIC	LRNSLDDLV	DEG_APCC_DBOX_1	0.0556
p.L1039M	HCC1937	breast	COSMIC	LRNSLDDLV	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_APCC_DBOX_1	1030:1038	LRNSLDDLV	APC,CDC20,FZR1	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons