DegronMD

Uniprot ID: Q9Y6Q9

Source protein: Nuclear receptor coactivator 3

Source gene: NCOA3

Class: DEG_APCC_KENBOX_2

Location: 731:735

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8256

ASA_SCORE: 112.12

COIL: 0.6268

CONS_SCORE: 0.5463

DSS_SCORE: 0.4508

HELIX: 0.3608

FCONS_SCORE: 0.8927

RIG_SCORE: 0.7275

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V721A	TCGA-AP-A1DV	UCEC	TCGA	KKENN	DEG_APCC_KENBOX_2	0.0556
p.R744T	TCGA-BK-A139	UCEC	TCGA	KKENN	DEG_APCC_KENBOX_2	0.0833
p.Q724H	TCGA-DD-AAVX	LIHC	TCGA	KKENN	DEG_APCC_KENBOX_2	0.1389
p.L741P	DO1209	BRCA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.1667
p.Q736H	DO1127	BRCA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.3056
p.S725F	DO15286	HNSC	ICGC	KKENN	DEG_APCC_KENBOX_2	0.1667
p.R739I	DO228924	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.2222
p.Q734H	DO52283	LIHC	ICGC	KKENN	DEG_APCC_KENBOX_2	0.7582
p.L737R	DO221545	PACA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.2778
p.G729R	DO35735	PBCA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.2778
p.G729R	DO229502	SKCA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.2778
p.V731A	DO43186	UCEC	ICGC	KKENN	DEG_APCC_KENBOX_2	0.6936
p.V721I	SIDM01220	Glioma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0556
p.V721I	LNZTA3WT4	central_nervous_system	COSMIC	KKENN	DEG_APCC_KENBOX_2	0.0556
p.V731I	LNZTA3WT4	central_nervous_system	COSMIC	KKENN	DEG_APCC_KENBOX_2	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13378	Homeobox protein Hox-D8	DEG_APCC_KENBOX_2	253:257	KKENN	APC,CDC20,FZR1	0.5012	More...
P17481	Homeobox protein Hox-B8	DEG_APCC_KENBOX_2	202:206	KKENN	APC,CDC20,FZR1	0.8038	More...
P49454	Centromere protein F	DEG_APCC_KENBOX_2	485:489	KKENN	APC,CDC20,FZR1	0.9739	More...
Q17RS7	Flap endonuclease GEN homolog 1	DEG_APCC_KENBOX_2	882:886	KKENN	APC,CDC20,FZR1	0.8381	More...
Q5VV43	Dyslexia-associated protein KIAA0319	DEG_APCC_KENBOX_2	712:716	KKENN	APC,CDC20,FZR1	0.9185	More...
Q5VXU9	Protein shortage in chiasmata 1 ortholog	DEG_APCC_KENBOX_2	479:483	KKENN	APC,CDC20,FZR1	0.8057	More...
Q8IYD8	Fanconi anemia group M protein	DEG_APCC_KENBOX_2	867:871	KKENN	APC,CDC20,FZR1	0.9394	More...
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_APCC_KENBOX_2	731:735	KKENN	APC,CDC20,FZR1	0.8256	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons