DegronMD - P17481(HOXB8)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R197W	TCGA-CK-4951	COAD	TCGA	KKENN	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.1944
p.E216K	TCGA-E7-A7XN	BLCA	TCGA	KKENN	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.0556
p.E216K	DO51878	BLCA	ICGC	KKENN	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.0556
p.R196W	DO10582	COAD	ICGC	KKENN	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.1667
p.S212R	DO233792	GACA	ICGC	KKENN	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.1667
p.N204K	DO229038	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	202:206	Mutation altering degron motif	0.6918
p.K200N	SIDM00631	Breast Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.2778
p.K200N	ACH-001358	Breast Cancer	CCLE	KKENN	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.2778
p.K200N	MDA-MB-330	breast	COSMIC	KKENN	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.2778
p.K199N	MDA-MB-330	breast	COSMIC	KKENN	DEG_APCC_KENBOX_2	202:206	Mutation rewiring degron network	0.25

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons