DegronMD

Uniprot ID: P17481

Source protein: Homeobox protein Hox-B8

Source gene: HOXB8

Class: DEG_APCC_KENBOX_2

Location: 202:206

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8038

ASA_SCORE: 115

COIL: 0.7484

CONS_SCORE: 0.6246

DSS_SCORE: 0.4964

HELIX: 0.2356

FCONS_SCORE: 0.9669

RIG_SCORE: 0.7214

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R197W	TCGA-CK-4951	COAD	TCGA	KKENN	DEG_APCC_KENBOX_2	0.1944
p.E216K	TCGA-E7-A7XN	BLCA	TCGA	KKENN	DEG_APCC_KENBOX_2	0.0556
p.E216K	DO51878	BLCA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.0556
p.R196W	DO10582	COAD	ICGC	KKENN	DEG_APCC_KENBOX_2	0.1667
p.S212R	DO233792	GACA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.1667
p.N204K	DO229038	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.6918
p.K200N	SIDM00631	Breast Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.2778
p.K200N	ACH-001358	Breast Cancer	CCLE	KKENN	DEG_APCC_KENBOX_2	0.2778
p.K200N	MDA-MB-330	breast	COSMIC	KKENN	DEG_APCC_KENBOX_2	0.2778
p.K199N	MDA-MB-330	breast	COSMIC	KKENN	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13378	Homeobox protein Hox-D8	DEG_APCC_KENBOX_2	253:257	KKENN	APC,CDC20,FZR1	0.5012	More...
P17481	Homeobox protein Hox-B8	DEG_APCC_KENBOX_2	202:206	KKENN	APC,CDC20,FZR1	0.8038	More...
P49454	Centromere protein F	DEG_APCC_KENBOX_2	485:489	KKENN	APC,CDC20,FZR1	0.9739	More...
Q17RS7	Flap endonuclease GEN homolog 1	DEG_APCC_KENBOX_2	882:886	KKENN	APC,CDC20,FZR1	0.8381	More...
Q5VV43	Dyslexia-associated protein KIAA0319	DEG_APCC_KENBOX_2	712:716	KKENN	APC,CDC20,FZR1	0.9185	More...
Q5VXU9	Protein shortage in chiasmata 1 ortholog	DEG_APCC_KENBOX_2	479:483	KKENN	APC,CDC20,FZR1	0.8057	More...
Q8IYD8	Fanconi anemia group M protein	DEG_APCC_KENBOX_2	867:871	KKENN	APC,CDC20,FZR1	0.9394	More...
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_APCC_KENBOX_2	731:735	KKENN	APC,CDC20,FZR1	0.8256	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons