DegronMD - Q5VXU9(SHOC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L1337P	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	KGNLFTD	LIG_APCC_ABBAyCdc20_2	1326:1332	Mutation rewiring degron network	0.1944
p.L1337P	COR-L105	lung	COSMIC	KGNLFTD	LIG_APCC_ABBAyCdc20_2	1326:1332	Mutation rewiring degron network	0.1944
p.G492R	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	KKENN	DEG_APCC_KENBOX_2	479:483	Mutation rewiring degron network	0.0833
p.G492R	HH	haematopoietic and lymphoid tissue	COSMIC	KKENN	DEG_APCC_KENBOX_2	479:483	Mutation rewiring degron network	0.0833
p.F486Y	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	KKENN	DEG_APCC_KENBOX_2	479:483	Mutation rewiring degron network	0.25
p.F486Y	HH	haematopoietic and lymphoid tissue	COSMIC	KKENN	DEG_APCC_KENBOX_2	479:483	Mutation rewiring degron network	0.25
p.P493L	SIDM01045	Endometrial Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	479:483	Mutation rewiring degron network	0.0556
p.P493L	EN	endometrium	COSMIC	KKENN	DEG_APCC_KENBOX_2	479:483	Mutation rewiring degron network	0.0556
p.N483T	SIDM00290	Gastric Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	479:483	Mutation altering degron motif	0.5944
p.N483T	HGC-27	stomach	COSMIC	KKENN	DEG_APCC_KENBOX_2	479:483	Mutation altering degron motif	0.5944
p.L1322W	SIDM01051	Ovarian Carcinoma	GDSC	KGNLFTD	LIG_APCC_ABBAyCdc20_2	1326:1332	Mutation rewiring degron network	0.2222
p.L1322W	EFO-27	ovary	COSMIC	KGNLFTD	LIG_APCC_ABBAyCdc20_2	1326:1332	Mutation rewiring degron network	0.2222
p.S1330T	HT55	large intestine	COSMIC	KGNLFTD	LIG_APCC_ABBAyCdc20_2	1326:1332	Mutation altering degron motif	0.7116
p.I476V	RS4-11	haematopoietic and lymphoid tissue	COSMIC	KKENN	DEG_APCC_KENBOX_2	479:483	Mutation rewiring degron network	0.25
p.S1330A	HEC-1	endometrium	COSMIC	KGNLFTD	LIG_APCC_ABBAyCdc20_2	1326:1332	Mutation altering degron motif	0.7588

Kaplan plot for SHOC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHOC1

UniProt ID: Q5VXU9

Entrez ID: 158401

Protein name: Protein shortage in chiasmata 1 ortholog (EC 3.6.-.-) (Protein ZIP2 homolog) (MZIP2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHOC1 in